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Mean Values of Oxidative Stress Parameters in Healthy Subjects

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ClinicalTrials.gov Identifier: NCT00313118
Recruitment Status : Withdrawn (Problems with recruiting)
First Posted : April 11, 2006
Last Update Posted : March 28, 2017
Sponsor:
Collaborator:
Laboratory Dr. Bayer GmbH, Stuttgart, Germany
Information provided by (Responsible Party):
Selim Orguel, University Hospital, Basel, Switzerland

Brief Summary:
Determination of the mean value of oxidative stress parameters in normals and of the plasma and serum levels, resp. of malondialdehyde, glutathion and superoxide dismutase in healthy subjects.

Condition or disease
Healthy

Detailed Description:

In certain situations, free radicals can be generated in an exaggerated manner and can injure tissues and organs by interacting with lipids, proteins, or DNA. So, oxidative stress has been implicated in a large number of human diseases. To survive, the human body has developed a complex, efficient, and highly adaptive antioxidant defense system. The eye is also protected against oxidative stress by several mechanisms involving antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD), as well as by low-molecular-weight antioxidants such as glutathion (GSH) and ascorbate.

Primary open-angle glaucoma (POAG) is a chronic, slowly progressive optic neuropathy, characterized by excavation of the optic nerve head (ONH) and a distinctive pattern of visual field (VF) defects. The disease is multifactorial in origin, so that besides more extensively investigated factors oxidative stress has also been proposed as a contributing factor in the etiology of glaucomatous optic neuropathy. Oxidative stress represents a harmful state defined by the presence of pathologic levels of reactive oxygen species (ROS) relative to antioxidant defense.

Therefore, it would be also important to determine whether there is a relationship between circulating levels of the defense parameters to oxidative stress like malondialdehyde, GSH and SOD, and the occurrence of POAG.

Since there are only the limits of variation for these defense parameters available, mean values of the plasma levels of malondialdehyde, glutathion and superoxide dismutase will be determined in healthy subjects.


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Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Determination of the Mean Values of Oxidative Stress Parameters in the Plasma of Healthy Subjects
Study Start Date : January 2006
Actual Primary Completion Date : September 2010
Actual Study Completion Date : December 2016



Biospecimen Retention:   None Retained
plasma


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
healthy persons
Criteria

Inclusion Criteria:

  • German native speakers
  • Age between 18-80 years
  • Healthy without medication
  • No ophthalmic disease

Exclusion Criteria:

  • Any history of ocular or systemic diseases or of drug or alcohol abuse
  • Any mentally impaired patient

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00313118


Locations
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Switzerland
University Eye Clinic Basel
Basel, BS, Switzerland, 4031
Sponsors and Collaborators
Selim Orguel
Laboratory Dr. Bayer GmbH, Stuttgart, Germany
Investigators
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Study Director: Selim Orgül, MD University Hospital, Basel, Switzerland

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Responsible Party: Selim Orguel, Prof. Dr., University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier: NCT00313118     History of Changes
Other Study ID Numbers: 067-KOA-2005-001
First Posted: April 11, 2006    Key Record Dates
Last Update Posted: March 28, 2017
Last Verified: March 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Selim Orguel, University Hospital, Basel, Switzerland:
oxidative stress parameters