Usefulness of Microbiological Tests in Community-Acquired Pneumonia
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|ClinicalTrials.gov Identifier: NCT00312741|
Recruitment Status : Unknown
Verified February 2009 by Hospital Arnau de Vilanova.
Recruitment status was: Recruiting
First Posted : April 11, 2006
Last Update Posted : February 27, 2009
|Condition or disease||Intervention/treatment|
|Community-Acquired Pneumonia||Procedure: empirical versus microbiological guided treatment|
In community-acquired pneumonia, identification of the etiologic agent has theoretically important advantages. For individual patients, it facilitates the administration of a targeted, narrow-spectrum antibiotic therapy that may improve the efficacy of treatment, and reduces risks of antibiotic-related toxicity. For the community, microbiologic results contribute to understanding the local microbial epidemiology of community-acquired pneumonia and the antimicrobial resistance patterns of pathogens, information that is essential in the instauration or modification of empiric treatment regimens.
Guidelines recommend that all admitted patients with community-acquired pneumonia should have a collection of two sets of blood cultures, a good quality sputum sample for Gram stain and culture, a sample of pleural fuid if present and, for severe patients, an urine sample for antigen detection. In contrast, several prospective studies (usually without include urinary tests) concluded that these microbiological studies have limited value in the management of patients admitted with community-acquired pneumonia.
In addition, microbiological studies could provide erroneous or incomplete information. Thus, investigations has showed false-positive results from pneumococcal antigen detection in urine caused by a frequent persistence of positivity after infection or a nasopharyngeal or bronchial colonization. Other authors suggested that community-acquired pneumonia is a polymicrobial infection; consequently, despite the detection of a true microorganism, treatment needs to be also addressed against other potential pathogenic agents.
The purpose of the study is to assess the clinical and the economic derived from the initial microbiological studies, including antigen detection tests in urine for Streptococcus pneumoniae and Legionella pneumophila, in patients with community-acquired pneumonia.
The hypothesis is that community-acquired pneumonia is usually a monomicrobial infection. Therefore, early detection of the etiology allows to select the most active, narrow-spectrum, and cheap, and less toxic antibiotic agent.
|Study Type :||Observational|
|Estimated Enrollment :||250 participants|
|Official Title:||Prospective Study on Benefits Derived From Microbiological Tests in Community-Acquired Pneumonia|
|Study Start Date :||April 2006|
|Estimated Study Completion Date :||May 2008|
- Clinical and economic consequences obtained with the antibiotic selection in basis to early mcrobiological results
- Importance of polimicrobial etiology in community-acquired pneumonia
- Practice usefulness of urinary antigen detection tests in pneumonia
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00312741
|Contact: Miquel Falguera, M.D.||0034-973248100 ext firstname.lastname@example.org|
|Hospital Arnau de Vilanova||Recruiting|
|Lleida, Spain, 25198|
|Contact: Miquel Falguera, M.D. 0034-973248100 ext 2679 email@example.com|
|Sub-Investigator: Agustin Ruiz-González, M.D.|
|Principal Investigator:||Miquel Falguera, M.D.||Hospital Arnau de Vilanova (Lleida)|