Working... Menu

Allergy Towards Grass and Bronchial Inflammation - Related to Immunotherapy and Exhaled Nitrogen Oxide

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00312312
Recruitment Status : Unknown
Verified September 2006 by Bispebjerg Hospital.
Recruitment status was:  Recruiting
First Posted : April 10, 2006
Last Update Posted : June 12, 2007
Information provided by:
Bispebjerg Hospital

Brief Summary:
The purpose of this study is to evaluate the immunomodulatory effect of treatment of allergic rhinitis symptoms with specific immunotherapy by measurement of pulmonary inflammatory markers, and among others, exhaled nitric oxide.

Condition or disease Intervention/treatment Phase
Asthma, Bronchial Allergic Rhinitis Hypersensitivity, Immediate Biological: Specific immunotherapy Not Applicable

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Does Specific Immunotherapy Possess Immunomodulative Effects at the Bronchial Mucosa Level Among Adults With Atopic Diseases?
Study Start Date : March 2006
Estimated Study Completion Date : December 2008

Primary Outcome Measures :
  1. Skin prick test
  2. Spirometry
  3. Methacholine provocation of the pulmonary system
  4. Exhaled nitric oxide
  5. Immunoglobulin E (IgE) status
  6. Sputum examination
  7. Condensation of exhaled air

Secondary Outcome Measures :
  1. Questionnaire

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age 18-45 years old
  • Skin prick test or RAS test and physical examination conclude that the patient will have a beneficial effect from specific immunotherapy

Exclusion Criteria:

  • Other diseases except atopic disease
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00312312

Layout table for location contacts
Contact: Thomas B Knudsen, Medical student +45 61 70 96 99
Contact: Vibeke Backer, M.D., M.D.Sci +45 35 31 30 69

Layout table for location information
Bispebjerg Hospital Recruiting
Copenhagen, Denmark, 2400 NV
Contact: Thomas B Knudsen, Medical student    +45 61 70 96 99   
Sub-Investigator: Thomas B Knudsen, Medical student         
Sponsors and Collaborators
Bispebjerg Hospital
Layout table for investigator information
Principal Investigator: Vibeke Backer, M.D., M.D.Sci Lungeforskningsenheden v/Bispebjerg hospital

Layout table for additonal information Identifier: NCT00312312     History of Changes
Other Study ID Numbers: SITNO
First Posted: April 10, 2006    Key Record Dates
Last Update Posted: June 12, 2007
Last Verified: September 2006

Keywords provided by Bispebjerg Hospital:
Allergic rhinitis
Exhaled nitric oxide
Specific immunotherapy
Atopic diseases

Additional relevant MeSH terms:
Layout table for MeSH terms
Rhinitis, Allergic
Hypersensitivity, Immediate
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Immune System Diseases
Nose Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Immunologic Factors
Physiological Effects of Drugs