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Percutaneous coronary intervention with a sirolimus-coated stent compared to minimally invasive bypass surgery in patients with isolated proximal left anterior descending coronary arteries in terms of non-inferiority of an end point combining mortality, acute myocardial infarction and rate of reintervention of the target vessel within one year.
Condition or disease
Coronary Artery Disease
Procedure: Stenting and minimally invasive bypass surgeryProcedure: PCI with DES
Randomised Comparison of Minimally Invasive Direct Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention With Drug-eluting Stents in Patients With Proximal Stenosis of the Left Anterior Descending Coronary Artery
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 100 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Single-vessel disease of the proximal LAD with a stenosis > 50% (multivessel disease only if further coronary vessel stenoses do not require treatment)
Patients with angina pectoris (CCS 1-4)
Asymptomatic patients if clear signs of ischemia in the segments supplied by the LAD as assessed by bicycle ergometry or treadmill and/or scintigraphically and/or stress echo
Patients for whom both methods of treatment are equally possible
Consensus between the cardiac surgeon and the cardiologist that both inclusion and exclusion criteria are met in the selected case
Informed consent of the patient.
Patients < 18 years
Previous coronary artery bypass surgery
Concomitant diseases that lead to a greater risk for each of the treatment strategies
Significant peripheral arterial occlusive disease
Concomitant disease with limited life expectancy (e.g. malignant tumours that have not been curatively treated)
Objective follow-up examination not possible due to physical or mental handicap
Participation in another study.
Angiographical exclusion criteria:
Left main stem stenosis
Multivessel disease for which surgical or interventional therapy on other vessel areas is required.
Diagonal/septal branch > 1.5 mm, which might be compromised by a stent
Need for acute intervention (e.g. acute myocardial infarction)