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Biomagnetic Signals of Intestinal Ischemia

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ClinicalTrials.gov Identifier: NCT00285545
Recruitment Status : Completed
First Posted : February 2, 2006
Last Update Posted : July 2, 2013
Sponsor:
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
William Richards, University of South Alabama

Study Description
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Brief Summary:
The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify abnormalities without surgical intervention.

Condition or disease
Ischemia

Detailed Description:
The electrical activity of the small intestine may contain important information that will help us diagnose gastrointestinal diseases. The major impediment to reducing mortality of mesenteric ischemia is the lack of a noninvasive diagnostic test that identifies the syndrome before extensive necrosis occurs. Mesenteric ischemia is caused by the lack of blood flow to the intestine. The Superconducting QUantum Interference Device (SQUID) measures the magnetic field of the intestinal smooth muscle. By comparing normal smooth muscle and that of patients with mesenteric ischemia, we hope to identify abnormal disease states without surgery.
Study Design
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Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Biomagnetic Signals of Intestinal Ischemia II
Study Start Date : January 2000
Actual Primary Completion Date : January 2013
Actual Study Completion Date : January 2013
Groups and Cohorts
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Group/Cohort
Good blood flow
Group with normal blood flow to small intestine
Poor blood flow
Group with partial ischemia to small intestine


Outcome Measures
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Primary Outcome Measures :
  1. To observe a difference in the magnetic activity between normal and diseased smooth muscle [ Time Frame: 2011 ]

Eligibility Criteria
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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Primary Care Clinic
Criteria

Inclusion Criteria:

  • Normal Subjects and those diagnosed with mesenteric ischemia

Exclusion Criteria:

  • Subjects who report a tendency toward claustrophobia
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00285545


Locations
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United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Sponsors and Collaborators
University of South Alabama
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
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Principal Investigator: William O Richards, MD Vanderbilt University Medical Center
More Information
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Responsible Party: William Richards, principal investigator, University of South Alabama
ClinicalTrials.gov Identifier: NCT00285545    
Other Study ID Numbers: DK58197
R01DK058197 ( U.S. NIH Grant/Contract )
First Posted: February 2, 2006    Key Record Dates
Last Update Posted: July 2, 2013
Last Verified: June 2013
Keywords provided by William Richards, University of South Alabama:
Blood Supply
Mesentery
Additional relevant MeSH terms:
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Ischemia
Pathologic Processes