Mycophenolate Mofetil in Myasthenia Gravis

• ClinicalTrials.gov Identifier: NCT00285350
• Recruitment Status: Completed
• First Posted: February 2, 2006
• Last Update Posted: March 25, 2015
• Sponsor: FDA Office of Orphan Products Development
• Collaborator: Duke University
• Information provided by: FDA Office of Orphan Products Development

Study Description

Brief Summary:

This is a prospective, multi-center, double-blind, placebo-controlled trial to determine the efficacy and safety of mycophenolate mofetil (MM) in combination with prednisone as the initial form of immunosuppression in patients with acquired myasthenia gravis (MG).

Condition or disease	Intervention/treatment	Phase
Myasthenia Gravis	Drug: mycophenolate mofetil	Phase 3

Detailed Description:

80 patients with seropositive MG at 18 academic centers will be randomized to 3 months of treatment with 2.5 gm MM/day (1,250 mg q 12 hours, +/- 2 hours) plus 20 mg prednisone/day versus placebo plus 20 mg/day prednisone. The primary measure of efficacy will be the change from baseline in Quantitative MG (QMG) score at the end of 3 months. Secondary outcome measures include survival analysis for treatment failure, MG-related impairment of daily activities, functional assessment, manual muscle testing, SF-36 Health Status, and serum concentration of antibodies to the acetylcholine receptor. Study completers will have the option of taking open-label MM for an additional 6 months, during which prednisone will be reduced to the lowest dose necessary to maintain the optimum clinical response.

Study Design

• Study Type: Interventional (Clinical Trial)
• Enrollment: 80 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Double
• Primary Purpose: Treatment
• Official Title: A Trial of Mycophenolate Mofetil in Myasthenia Gravis
• Study Start Date: September 2002
• Actual Study Completion Date: March 2007

Arms and Interventions

Outcome Measures

Primary Outcome Measures :

1. QMGS

Secondary Outcome Measures :

1. Multiple

Eligibility Criteria

• Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Criteria

Inclusion criteria

1. Acquired generalized MG diagnosed by one of the Principal Investigators based on:

   • Examination by site PI showing myasthenic weakness that is not limited to the ocular or peri-ocular muscles.
   • Elevated acetylcholine receptor antibodies.
   • Positive edrophonium chloride test or abnormal neuromuscular transmission demonstrated by single fiber EMG or repetitive nerve stimulation.
2. Aged at least 18.
3. Able to give informed consent.
4. Taking a constant dose of Mestinon for at least 2 weeks.
5. Symptom severity that would, in the judgment of the site investigator, justify initiation of immunosuppressive treatment.
6. Able and willing to comply with study requirements.

Exclusion criteria

1. Thymoma now or in the past.
2. Plasma exchange or IVIG treatment within 90 days of randomization.

3. Treatment with azathioprine, cyclosporine, mycophenolate mofetil, or other immunosuppressive medication since onset of MG. Treatment with prednisone or other corticosteroids within the previous 90 days.

   • Exception: patients may have taken doses of these immunosuppressant medications that are judged by the Principal Investigator to have been clinically insignificant, i.e. unlikely to produce improvement in MG.

4. Women of childbearing potential who are pregnant, breast-feeding or not practicing effective contraception.
5. Renal failure, active thyroid or hepatocellular disease, chronic infection, poorly controlled cardiac disease, or any other illness, including psychiatric disease, that would, in the opinion of the treating physician, make it unsafe for the patient to participate or would interfere with the interpretation of study results.
6. Weakness affecting only ocular or peri-ocular muscles (Myasthenia Gravis Foundation of America Class I).
7. Severe weakness predominantly affecting oropharyngeal, respiratory muscles or both (MGFA Class IVB).
8. Crisis or impending crisis (defined as FVC <10ml/Kg or bulbar weakness severe enough to compromise airway protection.)
9. Hemoglobin <10mg/dl; WBC <3,500.
10. History of non-compliance with treatment and office visits.
11. Thymectomy within 12 months before randomization.
12. Concurrent medical condition that would pose an unacceptable risk from immunosuppression, including a positive skin test for tuberculosis (PPD), unless the patient has previously received appropriate treatment.

Contacts and Locations

Sponsors and Collaborators

FDA Office of Orphan Products Development

Duke University

Investigators

• Principal Investigator: Donald B Sanders, MD; Duke University

More Information

• ClinicalTrials.gov Identifier: NCT00285350
• Obsolete Identifiers: NCT00127894
• Other Study ID Numbers: 2154
• First Posted: February 2, 2006
• Last Update Posted: March 25, 2015
• Last Verified: March 2007

Keywords provided by FDA Office of Orphan Products Development:

myasthenia gravis

Additional relevant MeSH terms:

Muscle Weakness; Myasthenia Gravis; Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Pathologic Processes; Autoimmune Diseases of the Nervous System; Neuromuscular Junction Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases; Mycophenolic Acid; Antibiotics, Antineoplastic; Antineoplastic Agents; Antibiotics, Antitubercular; Antitubercular Agents; Anti-Bacterial Agents; Anti-Infective Agents; Enzyme Inhibitors; Molecular Mechanisms of Pharmacological Action