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PEEP Test and Gas Exchange in ALI/ARDS Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00284102
Recruitment Status : Completed
First Posted : January 31, 2006
Last Update Posted : September 25, 2008
Sponsor:
Information provided by:
Policlinico Hospital

Study Description
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Brief Summary:
The investigators aim to study the effect of different levels of PEEP in ALI/ARDS patients on gas exchange.

Condition or disease Intervention/treatment Phase
Acute Respiratory Distress Syndrome Procedure: Mechanical ventilation Not Applicable

Detailed Description:
In a population of ALI/ARDS patients during mechanical ventilation we will evaluate the effect of different levels of PEEP on gas exchange and dead space.
Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 50 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Positive End Expiratory Pressure (PEEP) Test and Gas Exchange in ALI/ARDS Patients
Study Start Date : January 2006
Actual Primary Completion Date : April 2008
Actual Study Completion Date : April 2008

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Arms and Interventions
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Arm Intervention/treatment
Experimental: 1
ALI/ARDS patients
 Procedure: Mechanical ventilation
measurement of gas exchange, dead space, respiratory mechanics 5, 15, 30, 60 minutes from PEEP change (5 and 15 cmH2O)


Outcome Measures
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Primary Outcome Measures :
  1. Gas exchange, dead space, respiratory mechanics [ Time Frame: 5, 15, 30, 60 minutes from PEEP change ]

Eligibility Criteria
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Ages Eligible for Study:   16 Years to 90 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ALI/ARDS patients requiring mechanical ventilation

Exclusion Criteria:

  • Hemodynamic instability
  • Barotrauma
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00284102


Locations
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Italy
Policlinico Hospital
Milano, Italy, 20122
Sponsors and Collaborators
Policlinico Hospital
Investigators
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Principal Investigator: Davide Chiumello, MD Policlinico Hospital
More Information
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Responsible Party: Davide Chiumello, Policlinico Hospital
ClinicalTrials.gov Identifier: NCT00284102    
Other Study ID Numbers: 1700
First Posted: January 31, 2006    Key Record Dates
Last Update Posted: September 25, 2008
Last Verified: September 2008
Keywords provided by Policlinico Hospital:
gas exchange
dead space
respiratory failure
ALI/ARDS patients
Additional relevant MeSH terms:
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Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Lung Diseases
Respiratory Tract Diseases
 Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Lung Injury