COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Effect of Exercise Intervention on Various Physiologic Factors That Change With Increasing Age

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00283673
Recruitment Status : Completed
First Posted : January 30, 2006
Last Update Posted : June 6, 2011
Information provided by:
Mayo Clinic

Brief Summary:
This study randomized healthy sedentary people age 20-80 years to 16 weeks of supervised exercise versus no exercise. Several end points were evaluated after 16 weeks including insulin sensitivity and muscle physiology.

Condition or disease Intervention/treatment Phase
Aging Behavioral: Exercise Not Applicable

Detailed Description:
Healthy subjects performing < 30 min exercise twice per week were studied prior to randomization and after of sixteen weeks exercise. They were randomized to sixteen weeks of supervised exercise performed on a stationary bike vs. placebo exercise (a series of flexibility exercises performed at home). Intensity, duration and frequency of exercise were gradually increased to four sessions per week lasting forty minutes each and achieving 80% target heart rate. Participants were weighed perioidically and counseled appropriately when weight changed by > 2 %. Insulin sensitivity and muscle mitochondrial protein synthesis were studied.

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Enrollment : 102 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Official Title: Impact of Aerobic Exercise Training on Age Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity
Study Start Date : September 1995
Actual Primary Completion Date : January 1998
Actual Study Completion Date : January 1998

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Insulin sensitivity

Secondary Outcome Measures :
  1. Muscle Mitochondrial Protein Synthesis
  2. mRNA of mitochondrial genes
  3. mRNA of genes involved in mitochondrial biogenesis

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   20 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Healthy subjects performing < 30 min exercise twice per week. Age 20-90 years. Willing to be randomized to exercise versus no exercise. Willing to be studied in General Clinical Research Center with studies including Muscle Biopsy.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00283673

Layout table for location information
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Layout table for investigator information
Principal Investigator: K. Sreekumaran Nair, M.D. Mayo Clinic
Publications of Results:
Layout table for additonal information Identifier: NCT00283673    
Other Study ID Numbers: 350-95
R01AG009531 ( U.S. NIH Grant/Contract )
First Posted: January 30, 2006    Key Record Dates
Last Update Posted: June 6, 2011
Last Verified: June 2011