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MR Assessment of Brain Function Altered by Lead Exposure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00283647
Recruitment Status : Completed
First Posted : January 30, 2006
Last Update Posted : April 14, 2015
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)

Brief Summary:
Exposure to lead during pregnancy, infancy, and childhood increases the individual likelihood of impaired school performance, increased impulsiveness, aggression, and delinquent behavior. Disorders that result from exposure to environmental neurotoxicants are a complex web of interactions between genetic, neurochemical, biochemical, environmental and social factors that influence children during critical periods of development. To date, research in the area of human developmental neurotoxicology focuses primarily on global measures of sensory-motor development and cognition. However, studies elucidating the biological basis for developmental and behavioral disorders due to environmental toxicant exposure are lacking. Although gross brain structure appears normal, underlying problems exist at a neural level. Our proposal seeks to relate childhood environmental lead exposure at various levels and stages of development with detriments in brain structure and neurochemical functioning assessed with magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Cortical and subcortical brain volumes will be determined with high resolution MRI. Neuronal and glial cell markers will be measured using proton MRS. These structural and chemical measures will also be correlated with behavioral measures from the young adult participants of the Cincinnati Lead Study (CLS). These participants represent a unique and ideal cohort of approximately 240 subjects with detailed histories of exposure and behavioral outcomes in lead exposed children monitored for approximately 20 years. A pilot study examining language, working memory and attention in combination with functional magnetic resonance imaging (fMRI) will also be performed to better understand the functional and behavioral deficits.

Condition or disease
Lead Exposure

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Study Type : Observational
Enrollment : 150 participants
Official Title: MR Assessment of Brain Function Altered by Lead Exposure
Study Start Date : October 2002
Actual Primary Completion Date : September 2006
Actual Study Completion Date : September 2006

Information from the National Library of Medicine

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Ages Eligible for Study:   19 Years to 26 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Participant in the Cincinnati Lead Study.
  2. Age range of at least 18 years with an upper limit of 25 years.
  3. Negative history for metabolic, neurologic, cardiac disease.
  4. Negative family history for metabolic or neurologic disease (in first-degree relatives only) to include genetic disorders.

Exclusion Criteria:

  1. Presence of an implant such as a hearing aid, cochlear implant, pacemaker or neuro-stimulator containing electrical circuitry or generating electrical signals or having moving metal parts.
  2. Presence of metal implants, orthopedic pins or plates above the level of the waist.
  3. Presence of orthodontic braces.
  4. Subjects who demonstrate or express noticeable anxiety and/or cannot readily communicate with personnel operating the MR equipment will be excluded.
  5. Pregnancy.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00283647

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United States, Ohio
Cincinnati Children's Hospital Medical Center, Dept. of Radiology and the Imaging Research Center
Cincinnati, Ohio, United States, 45229
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
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Principal Investigator: Kim M Cecil, PhD Children's Hospital Medical Center, Cincinnati
Layout table for additonal information Identifier: NCT00283647    
Other Study ID Numbers: 11261-CP-004
First Posted: January 30, 2006    Key Record Dates
Last Update Posted: April 14, 2015
Last Verified: April 2015
Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
lead exposure
magnetic resonance imaging
magnetic resonance spectroscopy
functional magnetic resonance
brain development