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Oligodendrocyte Progenitor Cell Culture From Human Brain

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00283023
Recruitment Status : Unknown
Verified August 2008 by Rajavithi Hospital.
Recruitment status was:  Recruiting
First Posted : January 27, 2006
Last Update Posted : August 5, 2008
Information provided by:
Rajavithi Hospital

Brief Summary:
Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells. Clinical trials of stem- or progenitor cell transplantation in multiple sclerosis are currently premature. The researchers developed a protocol for human oligodendrocyte progenitor cell culture from human brain for the treatment of demyelinating disease.

Condition or disease Intervention/treatment Phase
Demyelinating Diseases Procedure: Oligodendrocyte progenitor cell culture/craniotomy Phase 1

Detailed Description:
Oligodendrocyte progenitor cell line were cultures and will be transplanted into the patient with Multiple sclerosis.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Official Title: Phase 1: Oligodendrocyte Progenitor Cell Culture From Human Brain
Study Start Date : December 2007
Estimated Primary Completion Date : December 2010

Arm Intervention/treatment
Experimental: A
Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.
Procedure: Oligodendrocyte progenitor cell culture/craniotomy
Oligodendrocyte progenitor cell culture protocol of Rajavithi Hospital will be apply
Other Name: Rajavithi Oligodendrocyte progenitor cell culture protocol

Primary Outcome Measures :
  1. Number of oligodendrocyte progenitor cell differentiation [ Time Frame: one month ]

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Male or female 20-65 years of age
  • Informed consent
  • Has elective craniotomy surgery

Exclusion Criteria:

  • HIV, hepatitis, and other central nervous system (CNS) infections
  • Dementia, Alzheimer disease, and neurodegenerative disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00283023

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Contact: Subsai Kongsaengdao, M.D. +66-6-6596159

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Assistant Professor Subsai Kongsaengdao Recruiting
Bangkok, Thailand, 10400
Contact: Subsai Kongsaengdao, M.D.    66-86-6596159   
Contact: Piyathida Boontee, M.D.    66-81-8423854   
Sponsors and Collaborators
Rajavithi Hospital
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Principal Investigator: Subsai Kongsaengdao, M.D. Division of Neurology, Department of Medicine, Rajavithi Hospital : Thailand
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Responsible Party: Assistant Professor Subsai Kongsaengdao, Rajavithi Hospital Identifier: NCT00283023    
Other Study ID Numbers: RH-CMR-003
RVH-CMR-003 grant
First Posted: January 27, 2006    Key Record Dates
Last Update Posted: August 5, 2008
Last Verified: August 2008
Keywords provided by Rajavithi Hospital:
All selective craniotomy
Additional relevant MeSH terms:
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Demyelinating Diseases
Nervous System Diseases