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Genetics of Rolandic Epilepsy

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ClinicalTrials.gov Identifier: NCT00282854
Recruitment Status : Unknown
Verified August 2011 by King's College London.
Recruitment status was:  Recruiting
First Posted : January 27, 2006
Last Update Posted : December 6, 2011
Sponsor:
Collaborator:
National Institute of Neurological Disorders and Stroke (NINDS)
Information provided by:
King's College London

Study Description
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Brief Summary:
The purpose of this study is to find the genes that cause Rolandic epilepsy and its related traits.

Condition or disease
Epilepsy

Detailed Description:

Rolandic epilepsy (RE) is the most common type of childhood epilepsy-affecting more than 50,000 children in the United States-and has a complex genetic inheritance. The seizure prognosis is relatively benign, however, many children with RE also have problems with speech and language, reading, and motor coordination. Symptoms of the disorder overlap with more severe types of epilepsy.

The purpose of this study is to find the genes that influence RE and its related traits. Identifying genetic causes for the variants would improve diagnosis and allow for early intervention.

Researchers will enroll 1000 children with RE and 3000 controls for participation in the study. The scientists will request medical histories and (salivary) DNA samples from the participants. Participation can be completed by mail and telephone.

Results from this study should provide important information regarding diagnosis and prognosis of RE, may be useful in clinical management, and, eventually, may lead to a cure for this and other forms of epilepsy.

Study Design
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Study Type : Observational
Estimated Enrollment : 1000 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Genetics of Rolandic Epilepsy
Study Start Date : January 2005
Estimated Primary Completion Date : December 2013
Estimated Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Epilepsy

Groups and Cohorts
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Group/Cohort
Group I: Cases
Children with rolandic epilepsy
Group II: Controls
Individuals group matched to cases for ethnicity, sex and area of residence but lacking a primary brain disorder.


Outcome Measures
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Biospecimen Retention:   Samples With DNA
whole blood

Eligibility Criteria
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Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   3 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Community Sample
Criteria

Inclusion:

  • typical history of focal seizures
  • EEG centrotemporal sharp waves
  • age of onset 3-12 years
  • no previous epilepsy type (febrile seizures OK)
  • normal development
  • normal neurological examination
  • normal MRI/CT (if done)

Exclusion:

  • only history of secondary generalized seizures
  • atypical history/semiology
  • history and EEG inconsistent
  • abnormal EEG background
  • very early (<3yrs) or late (>12yrs) onset
  • global neurodevelopmental deficit
  • deviant neurodevelopment
  • structural imaging abnormality
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00282854


Contacts
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Contact: Deb Pal, MD, PhD 212 342 1237 dkp28@columbia.edu

Locations
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United States, New York
Mailman School of Public Health, Columbia University Medical Center, 722 West 168th St, 6th Floor Recruiting
New York, New York, United States, 10032
Contact: Deb Pal, MD, PhD    212-342-1237    dkp28@columbia.edu   
Sponsors and Collaborators
King's College London
National Institute of Neurological Disorders and Stroke (NINDS)
Investigators
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Principal Investigator: Deb K. Pal, MD, PhD Associate Research Scientist, Mailman School of Public Health, Columbia University Medical Center
More Information
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Additional Information:

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Responsible Party: Deb K Pal MD PHD, Columbia University
ClinicalTrials.gov Identifier: NCT00282854    
Other Study ID Numbers: 4727
R01NS047530 ( U.S. NIH Grant/Contract )
First Posted: January 27, 2006    Key Record Dates
Last Update Posted: December 6, 2011
Last Verified: August 2011
Keywords provided by King's College London:
epilepsy
Rolandic epilepsy
Additional relevant MeSH terms:
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Epilepsy
Epilepsy, Rolandic
Brain Diseases
Central Nervous System Diseases
 Nervous System Diseases
Epilepsies, Partial
Epileptic Syndromes