Cardiovascular Protective Effect of Spironolactone in Hemodialysis
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ClinicalTrials.gov Identifier: NCT00277693
Recruitment Status : Unknown
Verified December 2005 by Universidad de los Andes, Chile. Recruitment status was: Recruiting
The purpose of the present study is to determine if spironolactone is safe and effective in the treatment of cardiovascular complications in hemodialysis patients.
Condition or disease
Drug: Spironolactone (drug)
Cardiovascular complications are common in dialysis patients and comprise up to 50% of deaths in end-stage renal disease population. Hypertension and left ventricle hypertrophy occur in more than 70% of patients undergoing long-term hemodialysis therapy, and both contributes to mortality and morbidity.Recent clinical trials in chronic heart failure and post miocardial infarct heart failure patients have demonstrated a beneficial effect of a mineralocorticoid receptor blocker spironolactone, in adittion to standard therapy (RALES AND EPHESUS studies). The aim of the present study is to evaluate spironolactone treatment in hemodialysis patients.
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