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How Does Early Age Life Style Affect Bone Strength and General Health Parameters at Middle Age?

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00270608
Recruitment Status : Unknown
Verified November 2007 by Hadassah Medical Organization.
Recruitment status was:  Recruiting
First Posted : December 28, 2005
Last Update Posted : November 27, 2007
Information provided by:
Hadassah Medical Organization

Brief Summary:
The purpose of this study is to evaluate the effect of vigorous physical activity versus extremely sedentary life style during young age on the bone mineral density and general health in later life.

Condition or disease Intervention/treatment
Bone Diseases Procedure: Quantitative Computed Tomography of the tibia and spine Procedure: MRI of the spine and the right knee Procedure: Blood test

Detailed Description:

Bone strength and peak bone mass are preliminary determined by genetic factors. Life style, especially exercise, is also considered to have an important effect on bone strength. Bone has the ability to strengthen itself according to Wolff's Law. When bone is subjected to strains and/or strain rates higher than the usual, it responds by remodeling, strengthening its architecture. The ability is greatest in young individuals and decreases with age. In the elderly this ability is largely non-existent and bone mass is lost. Whether this loss leads to osteoporosis is largely a function of the peak bone mass achieved before the decline. 11% of males and 44 % of females over 50 suffer from osteoporosis in later life. To what extent vigorous exercising beginning at a young age can increase bone strength is not known.

The purpose of the proposed research is to quantify the effect of life style on bone strength and general health parameters by comparing two male populations, one sedentary and the other that has done demanding physical training: (1) Elite infantry recruits who were inducted into the I.D.F. in Feb 1983, did their basic training at Sanur and were part of the 1983 stress fracture project who completed three years of elite infantry service and continued to serve as combat soldiers in the reserves; (2) Yeshiva students who had profiles of 82 or 97 and received deferment from their military service in 1983 and since then have continued their studies and never served in the army.

50 subjects will be reviewed in each group. Measurements of weight, height, waist and abdominal girth, resting pulse and blood pressure will be made. The brachial/ankle blood pressure index will be recorded. MRI of the right knee to study potential degenerate changes will be done using a 1.5 Tesla General Electric Signa MR scanner. Quantitative Computed Tomography (QCT), one of the most popular and effective methods utilized for osteoporosis screening, will be performed to determine volumetric BMD, BMC, bone geometric properties and strength indexes of the tibia and lumbar spine.


Group I: 50 males (age 41-45), former elite Israeli infantry soldiers, selected randomly from those recruits who did their infantry basic training at Sanur in Feb. 1983 (all profiled 82 or 97) and completed their military service as combat soldiers will be compared to:

Group II: 50 age-, profile- and ethnically-matched Israeli citizens whose military service was deferred in 1983 because of Torah studies and who did not do army service and were not involved in any kind of physical training.

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: How Does Early Age Life Style Affect Bone Strength and General Health at Middle Age? Twenty-Five Year Follow-up Health Status Comparison of a Sedentary Versus Extremely Physically Active Population From an Early Age
Study Start Date : March 2007
Estimated Study Completion Date : November 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Bone Diseases

Intervention Details:
  • Procedure: Quantitative Computed Tomography of the tibia and spine
    a single time 1 minute procedure
  • Procedure: MRI of the spine and the right knee
    a single time 45 minutes procedure
  • Procedure: Blood test
    A single time procedure to check lipid profile and hemoglobin A1C

Biospecimen Retention:   Samples With DNA
whole blood

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Israeli males who were 17-22 years-old and received a military profile of either 82 or 97 in 1983

Inclusion Criteria:

  • Israeli military profile 82 or 97 at age 17-22

Exclusion Criteria:

  • Israeli military profile less than 82 at age 17-22
  • Former soldiers with shrapnel injuries will be excluded from MRI studies

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00270608

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Contact: Prof. Charles Milgrom, MD 972 50 787 4401

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Hadassah Medical Organization Recruiting
Jerusalem, Israel
Contact: Arik Tzukert, DMD    00 972 2 6776095   
Contact: Hadas Lemberg, PhD    00 972 2 6777572   
Principal Investigator: Prof. Charles Milgrom, MD         
Sponsors and Collaborators
Hadassah Medical Organization
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Principal Investigator: Prof. Charles Milgrom, MD Hadassah Medical Organization
Publications of Results:
Layout table for additonal information Identifier: NCT00270608    
Other Study ID Numbers: 12-17.02.06-HMO-CTIL
First Posted: December 28, 2005    Key Record Dates
Last Update Posted: November 27, 2007
Last Verified: November 2007
Keywords provided by Hadassah Medical Organization:
Peripheral vascular disease
Total body fat percentage
Additional relevant MeSH terms:
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Bone Diseases
Musculoskeletal Diseases