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Microvascular Reactivity.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00259701
Recruitment Status : Completed
First Posted : November 29, 2005
Last Update Posted : October 6, 2006
Information provided by:
Yale University

Brief Summary:
This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

Condition or disease Intervention/treatment
Diabetes Retinopathy Vascular Pathology Device: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin

Detailed Description:
Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.

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Study Type : Observational
Enrollment : 20 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.
Study Start Date : June 2005
Study Completion Date : September 2005

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria: diabetic. -

Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00259701

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United States, Connecticut
Yale School of Medicine
New HAven, Connecticut, United States, 06510
Sponsors and Collaborators
Yale University
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Principal Investigator: David G Silverman Yale School of Medicine

Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information Identifier: NCT00259701    
Other Study ID Numbers: HIC-12397-1
First Posted: November 29, 2005    Key Record Dates
Last Update Posted: October 6, 2006
Last Verified: November 2005
Keywords provided by Yale University:
Additional relevant MeSH terms:
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Retinal Diseases
Eye Diseases
Vasodilator Agents
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs