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Functional Lipids and Appetite Regulation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00259259
Recruitment Status : Completed
First Posted : November 29, 2005
Last Update Posted : January 21, 2009
Information provided by:
University of Copenhagen

Brief Summary:
To evaluate the short-term effects of structured lipids on appetite regulation.

Condition or disease Intervention/treatment Phase
Obesity Behavioral: SALATRIM Not Applicable

Detailed Description:

Background Obesity is a major health problem worldwide, and it is a risk factor for several chronic disorders. Even small changes in energy intake, leading to a positive balance may lead to weight gain over time. Thus, slight modifications in food intake, such as the inclusion of foods that effect energy balance, may prevent weight gain and even facilitate weight loss. Replacing dietary fat with low-calorie fat (LCF), such as modified triglycerides with medium and long chained PUFA.may be an efficient way to reduce body fat.

Bray et al. (2002) has shown a sustained weight loss of ~6 kg over a 9 month period where one-third of a fat-reduced diet (25% fat) was replaced by olestra. This weight loss can not solely be explained by the decreased caloric content of olestra. Thus, inhibition of appetite leading to lower food intake, may be a potential mechanism of the observed weight loss.

A reduced absorption of LCF leaves undigested fatty acids in the middle and lower intestine, which may generate increased feelings of satiety and decrease caloric intake due to regulating peptides and hormones such (CCK, GLP-1, etc.). In addition, intraduodenal fatty acids may also promote distension of the stomach and distension of the intestine, which are well-known gastrointestinal signals controlling mechanisms for food intake.

Taken together, in addition to the acute reduction in caloric intake, LCF may encourage a gastrointestinal hormone response promoting beneficial effects on appetite regulation and energy balance.

Aims To evaluate the short-term effects of LCF on


  • Appetite sensations after a meal (VAS)
  • Postprandiel secretion of appetite regulating hormones
  • Ad libitum caloric intake 4,5-h subsequent to a fixed meal


• Palatability of the test meal

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Study Type : Interventional  (Clinical Trial)
Enrollment : 22 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Prevention
Official Title: The Effect of Functional Lipids on Appetite Regulation in Man
Study Start Date : October 2005
Study Completion Date : December 2005

Primary Outcome Measures :
  1. Appetite
  2. energy intake
  3. Hormones

Secondary Outcome Measures :
  1. Palability

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy males
  • Normal weigh, e.i. BMI between 18,5-25 kg/m2
  • age 18-40 years

Exclusion Criteria:

  • donation of blood 3 monhts prior or during the study
  • gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease
  • smoking
  • consumption of more than 21 alcoholic drinks/week
  • elite athletes
  • on mediation
  • diet supplements

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00259259

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Department of Human Nutrition, The Royal Veterinary and Agricultural University
Frederiksberg C, Copenhagen, Denmark, 1958
Sponsors and Collaborators
University of Copenhagen
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Principal Investigator: Arne Astrup, Proffessor Department of human nutrition, The Royal Veterinary and Agricultural University

Layout table for additonal information Identifier: NCT00259259    
Other Study ID Numbers: (KF) 01 275625
First Posted: November 29, 2005    Key Record Dates
Last Update Posted: January 21, 2009
Last Verified: September 2006
Keywords provided by University of Copenhagen:
Appetite regulation
Energy intake