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The Serum Tissue Factor Level in Lung Cancer Patients as a Prognostic Factor

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00257179
Recruitment Status : Unknown
Verified June 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : November 22, 2005
Last Update Posted : March 14, 2006
Information provided by:
National Taiwan University Hospital

Brief Summary:
This study uses serum tissue factor and tissue factor inhibitor and factor VII to monitor the pre-coagulation status in lung cancer patients and to correlate the pre-coagulation status with clinical staging and prognosis.

Condition or disease
Lung Cancer

Detailed Description:

The staging of lung cancer was according to tumor size, involvement of lymph node and metastatic status. But there is a different prognosis in cancer patients of the same stage. The coagulation status of cancer patients was considered as an important possible prognostic factor. So in this study, we want to evaluate patients' coagulation status and find the relation of coagulation status and cancer status.

We thus propose a prospective study using coagulation factors in order to search for the relationship between cancer stage and pre-coagulation status in Taiwanese lung cancer patients. We will also evaluate the potential use of tissue factor as a prognosis predictor in lung cancer patients.

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Study Type : Observational
Enrollment : 200 participants
Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Study Start Date : June 2005

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with newly-diagnosed lung cancer
  • Serum from cancer-free healthy volunteers

Exclusion Criteria:

  • Chronic renal failure or end-stage renal disease [ESRD] (creatinine [Cr] > 2 )
  • Hyperlipidemia on statin therapy
  • Acute myocardial infarction
  • Tapal or Plavix use
  • Active thromboembolic event
  • Severe liver disease (> child B)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00257179

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Contact: Chong-Jen Yu, M.D., Ph.D. 886-2-2356-2905

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National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Chong-Jen Yu, M.D., Ph.D.    886-2-2356-2905      
Sponsors and Collaborators
National Taiwan University Hospital
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Principal Investigator: Chong-Jen Yu, M.D., Ph.D. National Taiwan University Hospital
Layout table for additonal information Identifier: NCT00257179    
Other Study ID Numbers: 9461700609
First Posted: November 22, 2005    Key Record Dates
Last Update Posted: March 14, 2006
Last Verified: June 2005
Keywords provided by National Taiwan University Hospital:
Tissue factor
Lung cancer
Tissue factor protein inhibitor
Factor VII
Factor X
Additional relevant MeSH terms:
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Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases