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The Effect of Broccoli Sprouts as a Nutritional Supplement in the Prevention of Cardiovascular Disease

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ClinicalTrials.gov Identifier: NCT00252018
Recruitment Status : Completed
First Posted : November 11, 2005
Last Update Posted : May 14, 2008
Information provided by:
Bispebjerg Hospital

Brief Summary:

The purpose of this study is to investigate whether a daily intake of dried broccoli sprouts will improve the endothelial function of the participants as measured by Flow mediated dilation (FMD)

The dried sprouts are chosen because broccoli sprouts are known as containing large amounts af the glucosinolate glucoraphanin which in vitro and in animal models has been shown to have a positive effect on the endothelium as measured by NO release.

Condition or disease Intervention/treatment Phase
Diabetes Mellitus Hypertension Hypercholesterolemia Cardiovascular Disease Behavioral: Daily intake of broccoli sprouts Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 160 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Prevention
Official Title: The Effect of Broccoli Sprouts as a Nutritional Supplement in the Prevention of Cardiovascular Disease.
Study Start Date : January 2006
Actual Primary Completion Date : March 2007
Actual Study Completion Date : March 2007

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Improvement of endothelial function as measured by FMD

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients suffering from hypertension, having a diastolic blood pressure of above 90 mm Hg or a systolic blood pressure of more than 140 mm Hg.
  • Patients suffering from NIDDM, according to present criteria for diagnosis of NIDDM:
  • People with dyslipidemia (combination of total cholesterol above 5, LDL cholesterol above 3 and HDL cholesterol below 1.1)
  • Healthy controls suffering from none of the above conditions, but otherwise (age, sex, BMI and lifestyle) corresponding to the patient groups.

Exclusion Criteria:

  • Patients under the age of 18 at inclusion in the study.
  • Pregnant or breastfeeding women
  • Women of childbearing age with no safe method of contraception
  • Patients receiving vitamin K-antagonists (coumarine, marcoumar etc)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00252018

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Bispebjerg Hospital
Copenhagen, Denmark, 2400
Sponsors and Collaborators
Bispebjerg Hospital
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Study Chair: Christian Torp-Pedersen, MD Bispebjerg Hospital Department of Cardiology

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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ClinicalTrials.gov Identifier: NCT00252018    
Other Study ID Numbers: KF 01-257/04
First Posted: November 11, 2005    Key Record Dates
Last Update Posted: May 14, 2008
Last Verified: May 2008
Keywords provided by Bispebjerg Hospital:
Nutritional supplement
Endothelial function
Flow mediated dilation
Additional relevant MeSH terms:
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Cardiovascular Diseases
Lipid Metabolism Disorders
Metabolic Diseases