Opiate-Induced Tolerance & Hyperalgesia in Pain Patients
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|ClinicalTrials.gov Identifier: NCT00246532|
Recruitment Status : Completed
First Posted : October 30, 2005
Last Update Posted : April 30, 2012
|Condition or disease||Intervention/treatment||Phase|
|Chronic Low Back Pain Opioid-induced Hyperalgesia||Drug: Morphine Drug: Placebo||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||139 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Opiate-Induced Tolerance & Hyperalgesia in Pain Patients|
|Study Start Date :||October 2005|
|Actual Primary Completion Date :||December 2008|
|Actual Study Completion Date :||August 2009|
Placebo Comparator: 1: Placebo Pill
This arm contains placebo medication.
Patients will receive placebo tablets.
Active Comparator: 2: Morphine
Patients will receive oral morphine therapy.
Patients will be given morphine sulfate oral medication until their back pain is adequately controlled.
- Pain Tolerance [ Time Frame: 1 month ]
- Pain Threshold [ Time Frame: 1 month ]
- Opioid Titration [ Time Frame: 1 month ]
- Pain Intensity [ Time Frame: 1 month ]
- Roland-Morris Disability Index [ Time Frame: 1 month ]
- Beck Depression Inventory [ Time Frame: 1 month ]
- Follow-Up Survey [ Time Frame: 1 year ]Patients were asked about their average pain levels and current medication usage
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00246532
|United States, California|
|Stanford University School of Medicine|
|Stanford, California, United States, 94025|
|Principal Investigator:||Lawrence F Chu, MD, MS||Stanford University|