Functional Magnetic Resonance Imaging (fMRI) Study of Memory in Children

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ClinicalTrials.gov Identifier: NCT00242905

Recruitment Status : Completed

First Posted : October 21, 2005

Last Update Posted : May 2, 2011

Sponsor:

Information provided by:

Assistance Publique - Hôpitaux de Paris

Study Description

Brief Summary:

Memory is a cognitive function whose development is still poorly documented in children, but which is often disturbed in temporal epilepsy. There are no studies about the disorders of episodic memory. The investigations using functional MRI (fMRI) are scarce, they do not involve this field and none are dedicated to children. The objectives of this project are to study the neuronal networks involved in episodic memory in normal children, as well as the disorders of episodic memory in children with epilepsy and the mechanisms of cognitive and cerebral reorganization in epilepsy.

Condition or disease	Intervention/treatment
Childhood Absence Epilepsy [Pyknolepsy]	Behavioral: Study of memory using MRI

Detailed Description:

Twenty children aged from 6 to 18 years with temporal and/or frontal epilepsy and 20 normal children in the same age range will undergo the following examinations in a unique day in the Unit Hospital F. JOLIOT(CEA in ORSAY, France):

complete neuropsychological evaluation including episodic memory,
structural MRI to quantify, using VBM, the potential abnormalities of the anatomical structures, to perform cognitive-morphological correlations, and to localize the neuronal networks activated on fMRI,
functional MRI using an original task of episodic memory, specifically dedicated to children and being under behavioural validation laboratory.

The analysis of fMRI data will be performed using SPM and taking into account the existence of epilepsy or not, of cerebral lesion or not, age, handedness, the side and location of epileptogenic focus, the age of seizure onset, and the type of antiepileptic treatment.

This study has been approved by the Ethic Committee in september 2004 (CCPPRB BICETRE, promotion of ASSISTANCE PUBLIQUE - HOPITAUX de PARIS).

Study Design

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Study Type :	Observational
Actual Enrollment :	52 participants
Observational Model:	Cohort
Time Perspective:	Prospective
Official Title:	Anatomical and Functional MRI Study of Episodic Memory in Epileptic Compared to Normal Children
Study Start Date :	October 2005
Actual Primary Completion Date :	February 2009
Actual Study Completion Date :	February 2009

Resource links provided by the National Library of Medicine

MedlinePlus Genetics related topics: Pyridoxal 5'-phosphate-dependent epilepsy Childhood absence epilepsy

MedlinePlus related topics: Epilepsy Memory

Genetic and Rare Diseases Information Center resources: Epilepsy Juvenile Absence

U.S. FDA Resources

Groups and Cohorts

Intervention Details:

Behavioral: Study of memory using MRI
Study of memory using MRI

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:	6 Years to 18 Years (Child, Adult)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes
Sampling Method:	Probability Sample

Study Population

Inclusion Criteria:

Parents or legal tutors of the children having given written consent to participate to the study, after having being fully informed.
Patients presenting with a temporal and/or frontal epilepsy and being able to perform the tasks of the protocol.
Controls being recruited among brothers, sisters, and friends of the patients and being right-handlers, without any neurological history or learning disorders.

Exclusion Criteria:

Any contra-indication to MRI or being claustrophobia or blind.

Criteria

Inclusion Criteria:

Parents or legal tutors of the children having given written consent to participate to the study, after having being fully informed.
Patients presenting with a temporal and/or frontal epilepsy and being able to perform the tasks of the protocol.
Controls being recruited among brothers, sisters, and friends of the patients and being right-handlers, without any neurological history or learning disorders.

Exclusion Criteria:

Any contra-indication to MRI or being claustrophobia or blind.

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00242905

Locations

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France
Service Hospitalier Frédéric Joliot (SHFJ)
Orsay, France, 91400
Necker Hospital
Paris, France, 75015

Sponsors and Collaborators

Assistance Publique - Hôpitaux de Paris

Investigators

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Principal Investigator:	Catherine CHIRON, MD,PhD	Assistance Publique - Hôpitaux de Paris

More Information

Publications:

Jambaqué I, Dellatolas G, Dulac O, Ponsot G, Signoret JL. Verbal and visual memory impairment in children with epilepsy. Neuropsychologia. 1993 Dec;31(12):1321-37.

Hertz-Pannier L, Chiron C, Jambaqué I, Renaux-Kieffer V, Van de Moortele PF, Delalande O, Fohlen M, Brunelle F, Le Bihan D. Late plasticity for language in a child's non-dominant hemisphere: a pre- and post-surgery fMRI study. Brain. 2002 Feb;125(Pt 2):361-72.

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Responsible Party:	Yannick VACHER, Department of Clinical Research of developpement
ClinicalTrials.gov Identifier:	NCT00242905
Other Study ID Numbers:	P040203
First Posted:	October 21, 2005 Key Record Dates
Last Update Posted:	May 2, 2011
Last Verified:	March 2007

Keywords provided by Assistance Publique - Hôpitaux de Paris:


Memory Epilepsy Children Magnetic resonance imaging Functional magnetic resonance imaging

Additional relevant MeSH terms:

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Epilepsy Epilepsy, Absence Brain Diseases Central Nervous System Diseases	Nervous System Diseases Epilepsy, Generalized Epileptic Syndromes

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