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Trial record 23 of 575 for:    CARBON DIOXIDE AND anesthesia

The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00242671
Recruitment Status : Completed
First Posted : October 20, 2005
Last Update Posted : August 5, 2010
Information provided by:
University Health Network, Toronto

Brief Summary:
The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.

Condition or disease Intervention/treatment Phase
Anesthesia Procedure: Isocapnic Hyperponea Phase 3

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Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane.
Study Start Date : October 2005
Actual Primary Completion Date : August 2008
Actual Study Completion Date : December 2008

Resource links provided by the National Library of Medicine

Drug Information available for: Sevoflurane

Primary Outcome Measures :
  1. Time to recovery from anesthesia as indicated by time to extubation and rate of change of BIS score

Secondary Outcome Measures :
  1. Quality of recovery in the recovery room as indicated by the level of consciousness, incidence of nausea, vomiting, shivering and other phenomena occuring during recovery

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion criteria:

  1. Elective gynecological procedure
  2. ASA I-III
  3. Age 18-80 years
  4. Signed informed consent

Exclusion criteria:

  1. ASA IV
  2. Patients with contra-indications to Sevoflurane anesthesia or other anesthetics included in the protocol
  3. Active smoking, asthma or other history of hyper-reactive airway disease
  4. History of chronic obstructive lung disease limiting exercise
  5. History of angina, previous myocardial infarction, valvular heart disease, or heart surgery
  6. Presence of heart murmurs or neck bruits
  7. ECT abnormalities including atrial fibrillation, prolonged P-R interval, prolonged Q-T interval, presence of Q waves in inferior, anterior or lateral leads, criteria for left ventricular hypertrophy, T-wave abnormalities,
  8. History of difficult airway access
  9. Pulmonary hypertension and/or right ventricle dysfunction
  10. History of bulous emphysema, and/or spontaneous pneumothorax
  11. History of alcohol or drugs abuse
  12. Known history of psychiatric illness and/or medications
  13. Patients that required postoperative mechanical ventilation for any reason

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00242671

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Canada, Ontario
Toronto General Hospital, University Health Network
Toronto, Ontario, Canada, M5G 2C4
Sponsors and Collaborators
University Health Network, Toronto
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Principal Investigator: Rita Katznelson, MD Toronto General Hospital, University Health Network

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Responsible Party: Rita Katznelson, Toronto General Hospital, University Health Network Identifier: NCT00242671     History of Changes
Other Study ID Numbers: UHN REB 05-0299-AE
First Posted: October 20, 2005    Key Record Dates
Last Update Posted: August 5, 2010
Last Verified: September 2006
Keywords provided by University Health Network, Toronto:
general anesthesia, hyperventilation, carbon dioxide, isocapnic hyperponea
Additional relevant MeSH terms:
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Central Nervous System Depressants
Physiological Effects of Drugs
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General