The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane
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The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 80 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Elective gynecological procedure
Age 18-80 years
Signed informed consent
Patients with contra-indications to Sevoflurane anesthesia or other anesthetics included in the protocol
Active smoking, asthma or other history of hyper-reactive airway disease
History of chronic obstructive lung disease limiting exercise
History of angina, previous myocardial infarction, valvular heart disease, or heart surgery
Presence of heart murmurs or neck bruits
ECT abnormalities including atrial fibrillation, prolonged P-R interval, prolonged Q-T interval, presence of Q waves in inferior, anterior or lateral leads, criteria for left ventricular hypertrophy, T-wave abnormalities,
History of difficult airway access
Pulmonary hypertension and/or right ventricle dysfunction
History of bulous emphysema, and/or spontaneous pneumothorax
History of alcohol or drugs abuse
Known history of psychiatric illness and/or medications
Patients that required postoperative mechanical ventilation for any reason