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ClinicalTrials.gov Identifier: NCT00229450
Recruitment Status : Unknown
Verified June 2008 by University of California, Los Angeles. Recruitment status was: Recruiting
First Posted : September 29, 2005
Last Update Posted : June 4, 2008
University of California, Los Angeles
National Alliance for Research on Schizophrenia and Depression
During perimenopause (the time just prior to menopause), women often notice many biological, psychological, and social changes. In particular, some women experience depressive symptoms during perimenopause that are severe enough to warrant antidepressant medication. Whether or not women with perimenopausal depression respond to antidepressant medication may depend on the level of estrogen in their blood. We would like to investigate whether estrogen will help the women who only partially respond to antidepressant medications. We also want to examine how different doses of estrogen may affect individuals differently.
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Layout table for eligibility information
Ages Eligible for Study:
40 Years to 60 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Clinical Diagnosis of Unipolar Major Depression, currently taking antidepressants
HAM-D between 10 and 17
History of Psychosis, breast cancer, smoking, dementia, clotting disorders