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Ischemia and Reperfusion Injury in the Human: An Observational Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00229047
Recruitment Status : Completed
First Posted : September 29, 2005
Last Update Posted : August 25, 2017
Sponsor:
Information provided by:
Lawson Health Research Institute

Brief Summary:
We, the researchers at Lawson Health Research Institute, propose to investigate the impact of surgical ischemia and reperfusion on skeletal muscle microcirculation using a hand-held microscope.

Condition or disease
Ischemia

Detailed Description:
We propose to investigate the impact of surgical ischemia and reperfusion on skeletal muscle microcirculation using a hand-held microscope.

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Study Type : Observational
Actual Enrollment : 20 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Ischemia and Reperfusion Injury in the Human: An Observational Study
Actual Study Start Date : April 2005
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2011

Group/Cohort
Vein Stripping
Patients undergoing elective varicose vein stripping in our vascular OR. Observe circulation in the exposed soleus/gastrocnemius muscle.




Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing routine and elective varicose vein stripping.
Criteria

Inclusion Criteria:

  • Patients undergoing femoral distal bypass procedures for chronic limb ischemia

Exclusion Criteria:

  • Any severe comorbid conditions (i.e., chronic obstructive pulmonary disease [COPD])

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00229047


Locations
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Canada, Ontario
Lawson Health Research Institute
London, Ontario, Canada, N6A 4G5
Sponsors and Collaborators
Lawson Health Research Institute
Investigators
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Study Director: Amit Badhwar, PhD Scientist
Principal Investigator: Tom Forbes, MD Vascular Surgeon

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Responsible Party: Dr. T. Forbes, Lawson Health Research Institute
ClinicalTrials.gov Identifier: NCT00229047    
Other Study ID Numbers: R-05-133
11268E
First Posted: September 29, 2005    Key Record Dates
Last Update Posted: August 25, 2017
Last Verified: August 2017
Keywords provided by Lawson Health Research Institute:
Ischemic Preconditioning
Microvascular Perfusion
Inflammation
Ischemia and Reperfusion
Chronic Limb Ischemia
Additional relevant MeSH terms:
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Reperfusion Injury
Ischemia
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Postoperative Complications