Vascular Response to Isoproterenol and β2 Adrenergic Receptor Polymorphisms
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|ClinicalTrials.gov Identifier: NCT00226551|
Recruitment Status : Completed
First Posted : September 27, 2005
Last Update Posted : October 29, 2008
Single nucleotide polymorphisms at codon 46 and 79 of the gene encoding for the ß2 adrenergic receptor (ß2AR) modify its pharmacological properties and may alter the response to ß2AR agonists. The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo.
Internal mammary leftover segments were collected from 96 patients undergoing coronary artery bypass graft operation. Four rings that were prepared from each specimen were allowed to reach equilibrium with physiological Krebs solution prior to precontraction with U46619. Using the organ bath technique, cumulative dose response curve of isoproterenol was constructed and mean EC50 calculated for each patient.
|Condition or disease||Intervention/treatment||Phase|
|Coronary Disease||Drug: Isoproterenol||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||100 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||ß2 Adrenergic Receptor Polymorphisms and Vasodilation of Internal Mammary Artery Induced by Isoproterenol|
|Study Start Date :||August 1999|
- Mean Ec50% in response to rising concentration of isoproterenol
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00226551
|Hadassah Medical Organization|
|Principal Investigator:||Yoseph Caraco, MD||Hadassah Medical Organization|