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ClinicalTrials.gov Identifier: NCT00226083
Recruitment Status :
(PI returned to India)
We are studying if sickle cell disease blood platelets are larger than normal and how they may cause obstruction of blood vessels. We are also trying to study the reasons why large platelets are found in patients with sickle cell disease.
Condition or disease
Sickle Cell Disease
Research volunteers are seen in the Outpatient Research Center by the Principal Investigator or another physician. A detailed history is obtained, a physical examination is performed, and blood (usually 4 tablespoons) is obtained for additional tests. The research volunteer's previous medical records will be requested. Upto 5 additional blood samples may be obtained in a subgroup of patients.
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Layout table for eligibility information
Ages Eligible for Study:
7 Years and older (Child, Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Adults and children with sickle cell disease (Hb SS)
Adults and children > 7 years of age with sickle cell disease (Hb SS) who are not taking hydroxyurea and are not receiving routine blood transfusion therapy.
Current hydroxyurea therapy or,
Hydroxyurea use within the past 3 months
Blood transfusion or exchange transfusion within the past 3 months