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The Natural Course of Trichophyton Tonsurans Carriage and Infection: A Molecular and Biochemical Evaluation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00224926
Recruitment Status : Completed
First Posted : September 23, 2005
Last Update Posted : September 19, 2011
Sponsor:
Collaborator:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by (Responsible Party):
Children's Mercy Hospital Kansas City

Brief Summary:
To explore carrier and infection status of T.tonsurans tinea capitis and characterize the host-pathogen interaction as it relates to the disease presentation. The general hypothesis for this study is as follows: the type of genotypic and phenotypic variant to which a child is exposed accounts for the presentation status observed in Trichophyton tonsurans infection.The global outcome of this investigation is to reveal potential new drug targets designed to improve treatment outcomes in these children.

Condition or disease Intervention/treatment
Tinea Capitis Procedure: Scalp Brushing

Detailed Description:

Tinea capitis is an overwhelmingly prevalent disease of childhood estimated to be present in approximately 1 in 20 children at any point in time with an equal number of children serving as carriers of the fungal pathogen. Despite the widespread nature of the disease, the natural course of the infection remains incompletely described. The study will be driven by the following hypothesis: the type of genotypic and phenotypic variant to which a child is exposed accounts for the presentation status observed in Trichophyton tonsurans infection.

A fungal scalp culture will be acquired from all participants using a brush culture technique. Samples will be collected once a month over a two year time period.

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Study Type : Observational
Actual Enrollment : 446 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Natural Course of Trichophyton Tonsurans Carriage and Infection: A Molecular and Biochemical Evaluation
Study Start Date : September 2003
Actual Study Completion Date : September 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Tinea Infections


Intervention Details:
  • Procedure: Scalp Brushing
    sterile, soft-head toothbrush massaged on scalp


Biospecimen Retention:   Samples With DNA
fungal scalp cultures


Information from the National Library of Medicine

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Ages Eligible for Study:   2 Years to 5 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
preschool aged children
Criteria

Inclusion Criteria:

  • Preschool aged children will be eligible.

Exclusion Criteria:

  • None

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00224926


Locations
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United States, Missouri
Children's Mercy Hospital
Kansas City, Missouri, United States, 64108
Sponsors and Collaborators
Children's Mercy Hospital Kansas City
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Investigators
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Principal Investigator: Susan Rahman, PharmD Children's Mercy Hosptials and Clinics

Additional Information:
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Responsible Party: Children's Mercy Hospital Kansas City
ClinicalTrials.gov Identifier: NCT00224926    
Other Study ID Numbers: PPRU 10704
First Posted: September 23, 2005    Key Record Dates
Last Update Posted: September 19, 2011
Last Verified: September 2011
Keywords provided by Children's Mercy Hospital Kansas City:
Tinea Capitis
Additional relevant MeSH terms:
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Tinea Capitis
Infection
Tinea
Dermatomycoses
Skin Diseases, Infectious
Mycoses
Skin Diseases
Scalp Dermatoses