CHROENDOHNPCC: Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer Syndrome
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The aim of the study is to test the hypothesis that a chromoscopy colonoscopy is able to increase by 50 % the number of pre-cancer lesions or early cancer detected in patients with HNPCC syndrome, compared to a routine colonoscopy without chromoscopy.
Condition or disease
Colorectal Neoplasms, Hereditary Nonpolyposis
Procedure: Colonoscopy with chromoscopy
Patient with HNPCC syndrome confirmed by a mutation (MLH1, MSH2, MHS1) are involved in the study. Patient have 2 colonoscopy back to back. The second coloscopy is associated to chromoscopy with carmin indigo. Endoscopist are randomised for the colonoscopy with chromoscopy and are un-awarded of the result of the first colonoscopy. Histopathology of the polyp are noted. The follow up were 1 month.
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Layout table for eligibility information
Ages Eligible for Study:
25 Years to 75 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with MLH1, MSH2 or MSH6 mutation.
Patients concerned by early detection colonoscopy.
Coloscopy of tracking since less 1an
occlusive Syndrome contra-indicating the preparation for a total coloscopies
medical Conditions or serious illnesses contra-indicating a coloscopy of screening
pregnant Woman or nursing
Anomaly of coagulation contra-indicating the realization of biopsies and/or the exeresis of the lesion colorectal