Cancer Detection in Pancreatic Cysts
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00222898 |
Recruitment Status :
Completed
First Posted : September 22, 2005
Last Update Posted : February 19, 2007
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Condition or disease | Intervention/treatment |
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Pancreatic Cyst Pancreatic Pseudocyst Pancreatic Neoplasm | Procedure: DNA analysis of pancreatic cyst fluid / buccal swab |
The study of pancreatic diseases is hindered by the organ's deep seated location and especially lack of symptoms during the early stages of disease development and progression e.g. pancreatic cancer. This is particularly true of pancreatic cysts, the variety and the malignant potential of which encompass a broad spectrum. The radiological features distinguishing a benign from a pre-malignant to a frankly malignant cyst in the pancreas are frequently underwhelming and have lead to the clinical practice of sampling all but the most obvious. The yield of the aspirate in turn is frequently not of a quality upon which a clinical decision can be based.
Most would agree that the best approach for management of pancreatic cystic neoplasm lies in early diagnosis, ideally at a precancerous stage. The effectiveness and applicability of this study is the based on the ability of the cyst DNA analysis to stratify the patients at risk of developing pancreatic cancer based on the extent of accumulated mutational damage.
Study Type : | Observational |
Enrollment : | 300 participants |
Observational Model: | Defined Population |
Time Perspective: | Other |
Official Title: | Pancreatic Cyst DNA Analysis |
Study Start Date : | June 2004 |


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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Previously scheduled for Endoscopic ULtrasound for evaluation of pancreatic cyst
Exclusion Criteria:
- Any condition that would preclude safe performance of EUS/FNA

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00222898
United States, Indiana | |
Indiana University - Purdue University Indianapolis | |
Indianapolis, Indiana, United States, 46202 | |
United States, Massachusetts | |
Partners HealthCare System | |
Boston, Massachusetts, United States, 02114 | |
United States, Missouri | |
Washington University Medical Center | |
St. Louis, Missouri, United States, 63110 | |
United States, Pennsylvania | |
University of Pennsylvania | |
Philadelphia, Pennsylvania, United States, 19104 | |
University of Pittsburgh | |
Pittsburgh, Pennsylvania, United States, 15213 | |
VA Pittsburgh Healthcare System | |
Pittsburgh, Pennsylvania, United States, 15240 | |
United States, South Carolina | |
Medical University of South Carolina | |
Charleston, South Carolina, United States, 29425 |
Principal Investigator: | Asif Khalid, MD | University of Pittsburgh |
ClinicalTrials.gov Identifier: | NCT00222898 |
Other Study ID Numbers: |
PANDA |
First Posted: | September 22, 2005 Key Record Dates |
Last Update Posted: | February 19, 2007 |
Last Verified: | February 2007 |
Pancreatic Cyst PANDA Study |
Cysts Pancreatic Neoplasms Pancreatic Cyst Pancreatic Pseudocyst Neoplasms Pathological Conditions, Anatomical |
Digestive System Neoplasms Neoplasms by Site Endocrine Gland Neoplasms Digestive System Diseases Pancreatic Diseases Endocrine System Diseases |