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Fear Potentiation and Fear Inhibition in Posttraumatic Stress Disorder

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00209040
Recruitment Status : Completed
First Posted : September 21, 2005
Last Update Posted : August 7, 2019
Sponsor:
Information provided by (Responsible Party):
Erica Duncan, MD, Emory University

Brief Summary:
The current study will investigate the ability of people with and without fear symptoms after trauma to inhibit fear in an experimental situation.

Condition or disease Intervention/treatment Phase
Posttraumatic Stress Disorder Behavioral: Acoustic Startle Testing Not Applicable

  Show Detailed Description

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 425 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Fear Potentiation and Fear Inhibition in Posttraumatic Stress Disorder
Study Start Date : January 2001
Actual Primary Completion Date : February 22, 2012
Actual Study Completion Date : February 22, 2012

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: 1
Subjects with posttraumatic stress disorder
Behavioral: Acoustic Startle Testing
See protocol description for methodological details

Active Comparator: 2
Healthy controls
Behavioral: Acoustic Startle Testing
See protocol description for methodological details

Active Comparator: 3
Combat controls
Behavioral: Acoustic Startle Testing
See protocol description for methodological details




Primary Outcome Measures :
  1. Fear potentiation of acoustic startle [ Time Frame: Baseline ]
    Percent change in acoustic startle magnitude during visual cue conditioned to aversive stimuli, compared to trials without aversive stimuli



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age 18-80
  • Diagnosis of PTSD
  • Healthy controls (no history of PTSD)
  • Combat controls (no history of PTSD)

Exclusion Criteria:

  • No drug or alcohol abuse or dependence

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00209040


Locations
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United States, Georgia
Atlanta VA Medical Center
Decatur, Georgia, United States, 30033
Sponsors and Collaborators
Emory University
Investigators
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Principal Investigator: Erica Duncan, MD Emory University/Atlanta VA Medical Center

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Responsible Party: Erica Duncan, MD, Professor, Emory University
ClinicalTrials.gov Identifier: NCT00209040     History of Changes
Other Study ID Numbers: IRB00000983
First Posted: September 21, 2005    Key Record Dates
Last Update Posted: August 7, 2019
Last Verified: August 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by Erica Duncan, MD, Emory University:
PTSD
Acoustic startle
Additional relevant MeSH terms:
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Disease
Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Pathologic Processes
Trauma and Stressor Related Disorders
Mental Disorders