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Terminal Graft Failure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00208884
Recruitment Status : Terminated
First Posted : September 21, 2005
Last Update Posted : November 27, 2013
Information provided by (Responsible Party):
William T. Mahle, MD, Emory University

Brief Summary:

One of the risks associated with heart transplantation is failure of the graft. A graft is where the new heart is attached to the original vessels in the body. Approximately 10% of children suffer graft failure which, leads to heart failure and possible death. The problem is that we do not know some of the causes of graft failure thus, it is difficult to diagnose early and treat. Due to graft failure, lots of children are placed back on the transplant list and receive another new heart.

In this study, we plan to perform a retrospective chart review looking to see if we can correlate graft failure with a problem with the vessels called coronary allograft vasculopathy or rejection. In order to do this, we will collect data from patient's charts that have been diagnosed with graft failure and compare their clinical presentation/data to pathology reports of the explanted hearts from these children. Explanted hearts are the old transplanted hearts that are removed in order to put a new heart into the body. Explanted hearts at our institution are always sent to pathology for analysis thus it will be quite easy to perform this review.

Condition or disease
Orthotopic Heart Transplantation Graft Failure

Detailed Description:

The objectives are to describe the pathology findings from the examination of the explanted heart and correlate them with clinical variables such as catheterization data.

Children's Healthcare of Atlanta performs approximately 12-15 heart transplants a year. To date, there have been 19 re-transplantations for late graft failure at Children's. The pathologic and clinical records of these 19 patients will be studied. All data collected will be entered into a database for future analysis.

Data Collection

A retrospective review of standard pathology findings from the examination of the explanted hearts will be conducted in order to determine the following:

  1. Evidence of CAV (coronary allograft vasculopathy)
  2. Evidence of Endocardial fibroelastosis
  3. Evidence of Rejection (acute and chronic)
  4. Evidence of Myocardial infarction
  5. Evidence of Fibrosis
  6. Evidence of Fatty infiltration

A retrospective review of patient charts will also be utilized to compare the pathologic findings to clinical data obtained prior to re-transplantation. The following information will be collected:

  1. Type of transplant method
  2. Patient age at time of transplant
  3. Echocardiographic Data including Tissue Doppler Imaging (if available)
  4. Catheterization data

    1. CAV as identified by coronary angiography
    2. Ventricular end-diastolic pressure
    3. Cardiac index
    4. Ventricular ejection fraction
  5. Clinical rejection history

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Study Type : Observational
Enrollment : 19 participants
Time Perspective: Retrospective
Official Title: Terminal Graft Failure: A Combined Pathologic and Clinical Study
Study Start Date : October 2003
Study Completion Date : November 2005

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • retransplanted at Children's Healthcare of Atlanta for late graft failure

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00208884

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United States, Georgia
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Emory University
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Principal Investigator: William Mahle, MD Emory University and Children's Healthcare of Atlanta

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Responsible Party: William T. Mahle, MD, Principal Investigator, Emory University Identifier: NCT00208884     History of Changes
Other Study ID Numbers: 1001-2003
First Posted: September 21, 2005    Key Record Dates
Last Update Posted: November 27, 2013
Last Verified: November 2013
Keywords provided by William T. Mahle, MD, Emory University:
orthotopic heart transplantation
graft failure