Perioperative Effect of Atenolol on Cytokine Profiles
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00202358|
Recruitment Status : Unknown
Verified June 2008 by Saini Foundation.
Recruitment status was: Active, not recruiting
First Posted : September 20, 2005
Last Update Posted : June 17, 2008
Studies have shown that beta-blockers such as atenolol when given in the perioperative period reduce morbidity and mortality. One study showed that atenolol given just during the surgery period, seemed to improve outcomes up to 2 years later. This is hard to explain since beta-blockers act on the body by blocking the effects of adrenalin and thereby lowering heart rate and blood pressure.
This study is designed to find out if perioperative atenolol might exert its long term effects through an anti-inflammatory mechanism rather than by lowering heart rate and blood pressure. It is known that inflammation increases after surgery as part of the healing process. However, it is also becoming clear that low-grade chronic inflammation can also lead to long term adverse effects.
|Condition or disease||Intervention/treatment||Phase|
|Surgery||Drug: atenolol Drug: placebo||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||The Effect of Perioperative Atenolol on Post-Operative Cytokines|
|Study Start Date :||November 2002|
|Actual Primary Completion Date :||November 2007|
|Estimated Study Completion Date :||September 2008|
|Placebo Comparator: placebo||
- Postoperative levels of IL-6 and C-Reactive protein [ Time Frame: 6 hrs, 48 hrs, 6 weeks ]
- IL-10, TNF-α [ Time Frame: 6 hrs, 48 hrs, 6 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00202358
|United States, Massachusetts|
|Cape Cod Hospital|
|Hyannis, Massachusetts, United States, 02601|
|Principal Investigator:||Vikas Saini, M.D.||Dept Medicine, Cape Cod Hospital|