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Training at Different Intensities in Coronary Artery Disease -Effects on Myocardial Function

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00201591
Recruitment Status : Completed
First Posted : September 20, 2005
Last Update Posted : August 26, 2011
St. Olavs Hospital
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Brief Summary:
The study investigated if aerobic endurance exercise of different intensity has different impact on the physical capacity and myocardial function in patients with coronary artery disease. Patients with stable CAD trained for 10 weeks, and oxygen consumption and myocardial function were measured before and after this period. Patients were randomly assigned to each exercise group.

Condition or disease Intervention/treatment Phase
Coronary Artery Disease Behavioral: Exercise training for 10 weeks Not Applicable

Detailed Description:
Peak oxygen consumption was measured by gas-analysis. Myocardial function was measured by echocardiography. Exercise was performed on treadmills under close supervision of an exercise physiologist. Patients had to complete over 70% of sessions to be included in analysis. Three sessions were scheduled every week. Heart rate (HR) was about 85 % of max HR in the high intensity group, and about 65 % in the moderate intensity group.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 17 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Which Training Intensity is Most Effective in Improving Myocardial Function in Patients With Coronary Artery Disease?
Study Start Date : August 2002
Actual Primary Completion Date : January 2004
Actual Study Completion Date : January 2004

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Peak oxygen consumption

Secondary Outcome Measures :
  1. Quality of life
  2. Myocardial function measured by echocardiography

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • stable coronary artery disease
  • over 4 months since cardiovascular event

Exclusion Criteria:

  • heart failure
  • inability to exercise

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00201591

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Dept. of Circulation and Medical Imaging, NTNU
Trondheim, Norway, NO-7020
Sponsors and Collaborators
Norwegian University of Science and Technology
St. Olavs Hospital
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Study Chair: Stig A Slørdahl, Prof Norwegian University of Science and Technology
Publications of Results:
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Responsible Party: Norwegian University of Science and Technology Identifier: NCT00201591    
Other Study ID Numbers: Trehab I NTNU
First Posted: September 20, 2005    Key Record Dates
Last Update Posted: August 26, 2011
Last Verified: August 2011
Keywords provided by Norwegian University of Science and Technology:
Coronary artery disease
Exercise training
Aerobic Exercise
Additional relevant MeSH terms:
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Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases