COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00199628
Recruitment Status : Completed
First Posted : September 20, 2005
Last Update Posted : January 15, 2019
Information provided by (Responsible Party):
University Hospital, Limoges

Brief Summary:

Problems of compatibility between a mother and her child are frequent. The most well-known case can be illustrated by the fetomaternal blood group incompatibility (rhesus factor) which can induce severe anemia of the fetus.

The investigators recently proved that incompatibility between mother and child can concern an organ leading to a tissular alloimmunization. For example, neonatal membranous glomerulonephritis (a kidney disease) can result from this mechanism.

The purpose of this network is to detect and study neonatal diseases induced by tissular fetomaternal alloimmunization. The detection of these diseases will be performed by the mother's serum analysis.

Condition or disease
Glomerulonephritis, Membranous Neonatal Diseases and Abnormalities Hemochromatosis

Layout table for study information
Study Type : Observational
Actual Enrollment : 100 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization
Actual Study Start Date : September 2005
Actual Primary Completion Date : August 2013
Actual Study Completion Date : August 2014

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   Female
Gender Based Eligibility:   Yes
Gender Eligibility Description:   pregnant woman
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
pregnant woman

Inclusion Criteria:

Mothers having a child suffering from:

  • Neonatal membranous glomerulonephritis
  • Unexplained neonatal tubular defect
  • Unexplained thrombotic microangiopathy
  • Neonatal hemochromatosis

Exclusion Criteria:

  • Any cause explaining the child's disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00199628

Layout table for location information
Limoges University Hospital
Limoges, France, 87042
Sponsors and Collaborators
University Hospital, Limoges
Layout table for investigator information
Principal Investigator: Vincent Guigonis, MD Department of Pediatrics, Limoges University Hospital
Layout table for additonal information
Responsible Party: University Hospital, Limoges Identifier: NCT00199628    
Other Study ID Numbers: I05001
First Posted: September 20, 2005    Key Record Dates
Last Update Posted: January 15, 2019
Last Verified: September 2005
Keywords provided by University Hospital, Limoges:
fetomaternal tissular alloimmunization
Mothers having a child suffering from:
neonatal membranous glomerulonephritis
unexplained neonatal tubular defect
unexplained thrombotic microangiopathy
neonatal hemochromatosis
Additional relevant MeSH terms:
Layout table for MeSH terms
Glomerulonephritis, Membranous
Infant, Newborn, Diseases
Kidney Diseases
Urologic Diseases
Metal Metabolism, Inborn Errors
Metabolism, Inborn Errors
Genetic Diseases, Inborn
Iron Overload
Iron Metabolism Disorders
Metabolic Diseases
Autoimmune Diseases
Immune System Diseases