Impact of Exercise Training on Endothelial Function in CAD
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|ClinicalTrials.gov Identifier: NCT00176345|
Recruitment Status : Unknown
Verified September 2005 by University of Leipzig.
Recruitment status was: Recruiting
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention.
Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.
|Condition or disease||Intervention/treatment||Phase|
|Coronary Artery Disease||Behavioral: Exercise Training||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Impact of Exercise Training on Bradykinin-Mediated Endothelial Function in Patients With Coronary Artery Disease|
|Study Start Date :||January 2001|
- Endothelial function
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00176345
|Contact: Rainer P Hambrecht, MD||++49-341 865 ext email@example.com|
|Contact: Sandra Erbs, MD||++49-341 865 ext 1428||Sandra.Erbs@medizin.uni-leipzig.de|
|University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology||Recruiting|
|Leipzig, Saxony, Germany, 04289|
|Contact: Rainer P Hambrecht, MD ++49-341-865 ext 1428 firstname.lastname@example.org|
|Contact: Sandra Erbs, MD ++49-341-865 ext 1428 Sandra.Erbs@medizin.uni-leipzig.de|
|Principal Investigator: Rainer P Hambrecht, MD|
|Principal Investigator:||Rainer P Hambrecht, MD||University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology|