Working…
COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC: https://www.coronavirus.gov.

Get the latest research information from NIH: https://www.nih.gov/coronavirus.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Impact of Exercise Training on Endothelial Function in CAD

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00176345
Recruitment Status : Unknown
Verified September 2005 by University of Leipzig.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
Sponsor:
Information provided by:
University of Leipzig

Brief Summary:

Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention.

Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.


Condition or disease Intervention/treatment Phase
Coronary Artery Disease Behavioral: Exercise Training Phase 2

Detailed Description:

A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle.

Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Educational/Counseling/Training
Official Title: Impact of Exercise Training on Bradykinin-Mediated Endothelial Function in Patients With Coronary Artery Disease
Study Start Date : January 2001

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Endothelial function


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • stable CAD
  • male gender

Exclusion Criteria:

  • insulin-dependent diabetes mellitus
  • significant valvular heart disease
  • smoking
  • exercise-induced myocardial ischemia
  • conditions prohibiting exercise training

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00176345


Contacts
Layout table for location contacts
Contact: Rainer P Hambrecht, MD ++49-341 865 ext 1428 hamr@medizin.uni-leipzig.de
Contact: Sandra Erbs, MD ++49-341 865 ext 1428 Sandra.Erbs@medizin.uni-leipzig.de

Locations
Layout table for location information
Germany
University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology Recruiting
Leipzig, Saxony, Germany, 04289
Contact: Rainer P Hambrecht, MD    ++49-341-865 ext 1428    hamr@medizin.uni-leipzig.de   
Contact: Sandra Erbs, MD    ++49-341-865 ext 1428    Sandra.Erbs@medizin.uni-leipzig.de   
Principal Investigator: Rainer P Hambrecht, MD         
Sponsors and Collaborators
University of Leipzig
Investigators
Layout table for investigator information
Principal Investigator: Rainer P Hambrecht, MD University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology
Layout table for additonal information
ClinicalTrials.gov Identifier: NCT00176345    
Other Study ID Numbers: 639/97
157/02
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: September 15, 2005
Last Verified: September 2005
Keywords provided by University of Leipzig:
exercise training
endothelial function
Additional relevant MeSH terms:
Layout table for MeSH terms
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases