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Use of Procalcitonin in the Diagnosis of Pleural Effusion

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00172835
Recruitment Status : Unknown
Verified March 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 15, 2005
Last Update Posted : September 15, 2005
Information provided by:
National Taiwan University Hospital

Brief Summary:
Among several markers of inflammation and sepsis, procalcitonin (PCT) markers is being studied to investigate their accuracy for the diagnosis of bacterial infections. PCT is the prehormone of calcitonin, which is normally secreted by the C cells of the thyroid in response to hypercalcemia; under these normal conditions, negligible serumPCT concentrations are detected. The mechanism proposed for PCT production after inflammation and its role are still not completely known. It is believed that PCT is produced by the liver and peripheral blood mononuclear cells, modulated by lipopolysaccharides and sepsis-related cytokines. It binds to polysaccharides in pathogens, activating the classical complement pathway. The reported diagnostic accuracy of PCT for the diagnosis of bacterial infections has varied across studies.

Condition or disease
Pleural Effusion

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Study Type : Observational
Enrollment : 100 participants
Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Evaluation of Procalcitonin as a Diagnostic Tool for Patients With Pleural Effusion
Study Start Date : March 2005

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Clinical diagnosis of pleural effusion
  • Pleural effusion proved by chest sonography

Exclusion Criteria:

  • Conditions for which thoracentesis are contraindicated
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00172835

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Contact: Po-Ren Hsueh, MD 886-2-2356-5363

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National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Po-Ren Hsueh, MD    776-2-23565363   
Sponsors and Collaborators
National Taiwan University Hospital
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Principal Investigator: Po-Ren Hsueh, MD Department of Laboratory Medicine, National Taiwan University Hospital

Layout table for additonal information Identifier: NCT00172835     History of Changes
Other Study ID Numbers: 9461700208
First Posted: September 15, 2005    Key Record Dates
Last Update Posted: September 15, 2005
Last Verified: March 2005
Keywords provided by National Taiwan University Hospital:
pleural effusion
Additional relevant MeSH terms:
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Pleural Effusion
Pleural Diseases
Respiratory Tract Diseases