Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy
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This study is an investigation to compare the efficacy of two different intermittent sulfadoxine/pyrimethamine (SP) treatment regimens and intermittent sulfadoxine/pyrimethamine (SP) + artesunate (SP/AS) treatment of HIV negative and positive mothers in clearing placental parasitemia at delivery. If intermittent protective SP/AS treatment is equally efficacious and safe as intermittent protective SP, such a regimen could be adapted for programmatic use as a potentially more durable alternative to SP monotherapy in areas of increasing SP resistance.
Condition or disease
Drug: sulfadoxine/pyrimethamineDrug: sulfadoxine/pyrimethamine plus artesunate
Efficacy of Intermittent Sulfadoxine-Pyrimethamine and Sulfadoxine-Pyrimethamine + Artesunate Treatment in the Prevention of Malaria in Pregnancy in an Area With Chloroquine-Resistant Plasmodium Falciparum
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Layout table for eligibility information
Ages Eligible for Study:
15 Years and older (Child, Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Women 15 years of age or older
First or second pregnancy between 16 and 36 weeks gestation
Pregnancy prior to 16 weeks or after 36 weeks gestation
Third or later pregnancy;
Report previous allergic reactions to SP, AS, or unknown antimalarials;
If the distance to their home is too great or too inaccessible for follow-up;