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Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00164073
Recruitment Status : Unknown
Verified September 2005 by Bayside Health.
Recruitment status was:  Recruiting
First Posted : September 14, 2005
Last Update Posted : August 1, 2007
Sponsor:
Collaborator:
University of Adelaide
Information provided by:
Bayside Health

Brief Summary:
The purpose of this study is to examine gene expression profiles by DNA microarray in patients who are responders and non-responders to interferon and ribavirin treatment for hepatitis C virus (HCV). Genes involved in inflammation and fibrosis and mediators of the Th-1 lymphocyte response will be looked for. It is hoped that genetic targets for future more effective and less toxic treatments will be identified.

Condition or disease Intervention/treatment
Hepatitis C Procedure: Liver biopsy

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Defined Population
Time Perspective: Prospective
Official Title: Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection
Study Start Date : February 2004
Study Completion Date : February 2007

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • HCV mono-infection, no coagulopathy and having a liver biopsy for consideration of treatment

Exclusion Criteria:

  • Infection with HIV or HBV, excess ethanol (EtOH) consumption and other diseases of the liver

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00164073


Contacts
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Contact: Mark D Berzsenyi, MBBS 0417 574 015 m.berzsenyi@alfred.org.au

Locations
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Australia, Victoria
Alfred Hospital Recruiting
Melbourne, Victoria, Australia, 3181
Contact: Mark D Berzsenyi, MBBS    0417 574 015    m.berzsenyi@alfred.org.au   
Principal Investigator: Mark D Berzsenyi, MBBS         
Sponsors and Collaborators
Bayside Health
University of Adelaide
Investigators
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Principal Investigator: Mark D Berzsenyi, MBBS The Alfred
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ClinicalTrials.gov Identifier: NCT00164073    
Other Study ID Numbers: 122/03
First Posted: September 14, 2005    Key Record Dates
Last Update Posted: August 1, 2007
Last Verified: September 2005
Keywords provided by Bayside Health:
HCV and microarray
HCV
Additional relevant MeSH terms:
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Hepatitis A
Hepatitis C
Hepatitis C, Chronic
Virus Diseases
Hepatitis
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Flaviviridae Infections
Hepatitis, Chronic