Genetic Determinants of the Response to Salbutamol Among Asthma Patients
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|ClinicalTrials.gov Identifier: NCT00162396|
Recruitment Status : Unknown
Verified October 2008 by Hadassah Medical Organization.
Recruitment status was: Recruiting
First Posted : September 13, 2005
Last Update Posted : October 29, 2008
The response to salbutamol varies greatly among individuals. Data from previous studies indicate that some of the variability is accounted for by genetic polymorphisms in the gene encoding for the adrenoceptor subtype β2. The current study was designed to evaluate variability in the response to salbutamol among recently diagnosed patients who have not been treated by β2 agonists or corticosteroids.
Lung function tests will be performed prior to and following a single dose administration of salbutamol through inhalation. Additional pharmacodynamic indices will be monitored including pulse and blood pressure. Three samples of plasma will be drawn for the evaluation of salbutamol plasma concentration.
|Condition or disease||Intervention/treatment||Phase|
|Asthma||Drug: Albuterol||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||150 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Evaluation of Genetic Factors That May Account for Variability in the Response to Salbutamol Among Patients Suffering From Asthma|
|Study Start Date :||August 1999|
- Change in lung function tests after salbutamol inhalation
- Change in blood pressure and pulse after salbutamol inhalation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00162396
|Contact: Yoseph Caraco, MD||00 972 2 firstname.lastname@example.org|
|Hadassah Medical Organization||Recruiting|
|Jerusalem, Israel, 91120|
|Contact: Arik Tzukert, DMD : 00 972 2 6776095 email@example.com|
|Contact: Hadas Lemberg, PhD 00 972 2 6777572 firstname.lastname@example.org|
|Principal Investigator: Yoseph Caraco, MD|
|Principal Investigator:||Yoseph Caraco, MD||Hadassah Medical Organization|