Functional Brain Activation Patterns in Schizophrenia, Measured Before and After Treatment
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|ClinicalTrials.gov Identifier: NCT00161057|
Recruitment Status : Completed
First Posted : September 12, 2005
Last Update Posted : April 23, 2009
|Condition or disease|
|Schizophrenia Schizophreniform Disorders|
Schizophrenia is a heterogeneous disorder with a wide range of symptoms and signs including hallucinations, delusions, disorganisation, negative symptoms and cognitive deficits. Investigation of the neural substrates of the cognitive deficits in schizophrenia has revealed abnormalities in brain activity patterns. Particularly, earlier studies using functional FMRI conducted at the UMCU, revealed diminished language laterality, deficits in working memory and a reduced ability to automate cognitive processes. The aim of this project is to study the relationship between these brain activation patterns and neuroleptic treatment. More insight into psychopharmacological effects on brain physiology, may eventually enable us to better predict what effect treatment will have on patients.
Patients with a confirmed diagnosis of schizophrenia, schizophreniform disorder, schizoaffective disorder or psychotic disorder not otherwise specified (NOS), who are medication naive or medication free for a period of at least 2 weeks will be included. Patients will be tested before and after 8 weeks of treatment with an atypical antipsychotic. In the scanner patients will perform a working memory task, a language task and a visual-motor task. At study entry and after 8 weeks the PANSS, Clinical Global Impressions (CGI) and CDSS (Calgary Depression Scale of Schizophrenia) will be performed. Besides these patients, we will also include a group of matched healthy controls. We hypothesize that in medication naive or patients of-medication lateralization is reduced, and that efficiency of the working memory system is reduced. Lateralization is expected to correlate negatively with positive functions. We expect that antipsychotic treatment will normalize brain function and that the degree of normalization is correlated with the clinical measures of treatment efficacy.
|Study Type :||Observational|
|Actual Enrollment :||78 participants|
|Official Title:||Functional Brain Activation Patterns in Schizophrenia, Measured Before and After Treatment|
|Study Start Date :||December 2001|
|Actual Study Completion Date :||September 2008|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00161057
|Dept. of Psychiatry, UMC Utrecht|
|Utrecht, Netherlands, 3584 CX|
|Principal Investigator:||Nicoletta V Veelen||UMC Utrecht|
|Study Chair:||Rene Kahn, M.D. Ph.D.||UMC Utrecht|