COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

A Study on Risk Mutations of Vulnerability Genes of Schizophrenia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00155207
Recruitment Status : Unknown
Verified May 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 12, 2005
Last Update Posted : November 28, 2005
Information provided by:
National Taiwan University Hospital

Brief Summary:

This project entitled “A Study on Risk Mutations of the Vulnerability Genes of Schizophrenia” (RIGOS) is a continuous effort following the well founded and arduous work of genetic study on schizophrenia (SCH) by the Genomic Psychiatry Study Group (GENOP) of National Taiwan University Hospital. So far the GENOP has established several important data banks, including DNA bank and lymphoblastoid (EVB transformed) cell bank of 725 affected sib-pair SCH families, 200 Trio SCH families, and 150 normal controls; and the clinical database of serial follow-ups. An ongoing project, Positional Cloning Study on the Vulnerability Genes of SCH (POCOS), carried out by the GENOP has found 11 candidate vulnerability genes with identified expression in the brain. Besides, on the basis of two related projects, the Multiple Psychopathological Study of SCH (MPSS) and the Etiological Study on SCH (SEFOS), the GENOP has established endophotype indicators for schizophrenia in neuropsychological and neurophysiological domains. The GENOP, a multidisciplinary research team, is thus ready to search for risk mutations of the candidate vulnerability genes for schizophrenia in this new proposal.

The basic strategy of this RIGOS Project is to search for risk mutations, based on case-control design with sufficient statistical power, and then to validate these risk mutations by convergent evidence of genetic epidemiological analyses, functional variation studies using in vitro cell line experiments, microarray study, and neurophysiological study (PPI) on mice model. Thus, this RIGOS Project has integrated 5 lines of experimental designs to achieve 5 specific aims to identify and validate the risk mutations from 11 candidate vulnerability genes found in the ongoing POCOS project based on Taiwanese Sample.

We are confident to be at the frontier work of searching for the risk mutations, with functional validity, of SCH. The achievement of the RIGOS will be a mile stone to create new era of genetic functional study to tackle pathophysiological mechanism of SCH and will be the basis of developing novel diagnostic method and novel intervention method at the early stage of SCH in the future.

Condition or disease

Show Show detailed description

Layout table for study information
Study Type : Observational
Enrollment : 1065 participants
Observational Model: Defined Population
Time Perspective: Longitudinal
Time Perspective: Retrospective/Prospective
Official Title: A Study on Risk Mutations of Vulnerability Genes of Schizophrenia
Study Start Date : May 2005
Study Completion Date : April 2008

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Schizophrenia
  • There are two schizophrenia sib-paired children and one schizophrenia parent and the other one should be normal.

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00155207

Layout table for location contacts
Contact: Hai-Gwo Hwu, Professor 886-2-2312-3456 ext 6785

Layout table for location information
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 10002
Contact: Hai-Gwo Hwu, Professor    886-2-2312-3456 ext 6785   
Sponsors and Collaborators
National Taiwan University Hospital
Layout table for investigator information
Principal Investigator: Hai-Gwo Hwu, Professor National Taiwan University
Layout table for additonal information Identifier: NCT00155207    
Other Study ID Numbers: 9361701128
First Posted: September 12, 2005    Key Record Dates
Last Update Posted: November 28, 2005
Last Verified: May 2005
Keywords provided by National Taiwan University Hospital:
risk genetic mutation
vulnerability genes
affected sib-pairs
case-control design
animal model
functional validity
genetic epidemiological analysis
Additional relevant MeSH terms:
Layout table for MeSH terms
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders