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Automated Telephone System to Improve Treatment Adherence in People With Depression

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00136240
Recruitment Status : Completed
First Posted : August 29, 2005
Last Update Posted : July 25, 2013
National Institute of Mental Health (NIMH)
Information provided by:
Boston Medical Center

Brief Summary:
This study will determine the efficacy of a computerized telephone system called Telephone-Linked Care (TLC) in improving adherence to antidepressant medication regimens in people with depression.

Condition or disease Intervention/treatment Phase
Depression Behavioral: Computer Assisted Education for Behavior Change Not Applicable

Detailed Description:
The purpose of this study is to test the efficacy of a computerized telephone system called TLC (Telephone-Linked Care) in helping subjects adhere to their antidepressant medication regimens.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 144 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)
Official Title: Telecom System to Improve Adherence to Antidepressants
Study Start Date : April 2003
Actual Primary Completion Date : January 2006
Actual Study Completion Date : January 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Antidepressants

Primary Outcome Measures :
  1. Antidepressant medication adherence [ Time Frame: Measured monthly for 4 months ]
  2. Adherence to scheduled psychiatry clinic visits [ Time Frame: Measured monthly for 4 months ]

Secondary Outcome Measures :
  1. Depression status, measured by self-administered depression inventory scale [ Time Frame: Measured at baseline and at 4 month follow-up ]
  2. General health status, measured by self-rating health survey [ Time Frame: Measured at baseline and at 4 month follow-up ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • A clinical diagnosis of major depressive disorder, dysthymic disorder, depressive disorder not otherwise specified, or any combination of the three
  • Prescribed at least one antidepressant medication
  • Access to a telephone with touch-tone service
  • Speak and understand conversational English

Exclusion Criteria:

  • Current significant alcohol or drug abuse
  • Clinical diagnosis of bipolar disorder, schizoaffective disorder, or significant personality disorder
  • Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), or other neurodegenerative diseases
  • Alzheimer's disease and other dementia
  • Cancer, undergoing radiation therapy or chemotherapy
  • Suffering from Renal disease or on dialysis
  • Immunologic disorder (rheumatoid arthritis, systemic lupus erythematosus [SLE], etc.)
  • HIV
  • Terminal illness
  • Homeless
  • Legally blind
  • Planning to leave the geographic area during the study period

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00136240

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United States, Massachusetts
Boston Medical Center
Boston, Massachusetts, United States, 02118
Sponsors and Collaborators
Boston Medical Center
National Institute of Mental Health (NIMH)
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Study Director: Ramesh Farzanfar Boston University
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Responsible Party: Ramesh Farzanfar Identifier: NCT00136240    
Other Study ID Numbers: R21MH063937 ( U.S. NIH Grant/Contract )
R21MH063937 ( U.S. NIH Grant/Contract )
First Posted: August 29, 2005    Key Record Dates
Last Update Posted: July 25, 2013
Last Verified: August 2008
Additional relevant MeSH terms:
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Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders