Effects of Early Statin Treatment After Acute Myocardial Infarction (AMI) in Japanese Patients
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Statins have been shown to prevent coronary artery disease and to preserve left ventricular function in dilated cardiomyopathy. The investigators hypothesized that the early use of statins would reduce cardiovascular events including heart failure in acute myocardial infarction patients. The purpose of this study is to determine whether early (within 96 hours after onset) use of any available statins are effective to prevent cardiovascular events including heart failure after acute myocardial infarction in Japanese patients.
Condition or disease
Drug: lipid-lowering treatment
At least, in Japanese, it was controversial if lipid-lowering therapy to the patients whose total cholesterol levels <240 mg/dL was needed. Furthermore, in general, a role for early statin therapy in patients with ST-elevated AMI reperfused by primary PCI has not been clearly established. Statins have been shown to prevent coronary artery disease and to preserve left ventricular function in dilated cardiomyopathy. The investigators hypothesized that the early use of statins would reduce cardiovascular events including heart failure in acute myocardial infarction patients. A prospective, randomized, open-label, multicenter trial is conducted in AMI patients with normal total cholesterol levels (180-240 mg/dL). Patients are randomly assigned to receive any available statin within 96 hours of AMI onset or no statin and were followed for up to 24 months. The primary endpoint is a composite of cardiovascular death, nonfatal AMI, recurrent symptomatic myocardial ischemia, congestive heart failure, and stroke.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Clinical diagnosis of acute myocardial infarction
Serum total cholesterol levels on admission ranges ≥180 mg/dL and <240 mg/dL
Age < 18 years
Time from symptom onset to admission > 96 hours
Use of lipid-lowering agents within the previous 3 months
Known familial dyslipidemia
Severe renal failure
Known hepatic disease
Signs and symptoms of severe heart failure (Killip class III or IV)
A scheduled PCI or coronary artery bypass grafting (CABG)
A history of previous PCI (within 6 months) or CABG (within 3 months)