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Improved Stroke Outcome at 6 Months

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00122798
Recruitment Status : Completed
First Posted : July 22, 2005
Last Update Posted : June 27, 2006
RehaClinic Zurzach
Information provided by:
Kantonsspital Baden

Brief Summary:
The investigators implemented a structured chain of acute stroke care with early integrated rehabilitation. The mortality at 6 months was lower (12%) compared to 23% in the International Stroke Trial (IST) and 39% (67%) of the patients were dead or dependent, which is superior compared to international data.

Condition or disease Intervention/treatment
Stroke Procedure: Stroke treatment

Detailed Description:

Background/Aim of the study: To further reduce the 6 months stroke morbidity and mortality in a high volume stroke hospital and to compare the results with national and international data.

Methods: 204 consecutive stroke patients are analyzed in a prospective study in a single center teaching institution. The intervention consists of a structured therapeutic chain of 290 collaborating GPs, a standardised acute hospital proceeding overlapping with an early integrated neurovascular rehabilitation within the same institution. Primary endpoints include death and dependence at 6 months, secondary endpoints are the length of hospital stay (LOS) and the quantitative analysis of physical and psychosocial impairments. The data are directly compared with the same endpoints of the Swiss subgroup of the international stroke trial (IST) and recent international data.

Results: At 6 months, mortality is significantly lower with 12 % (compared to 23 % in the IST trial) and only 39 % (67 %) of the patients are dead or dependent. Stroke severity is similar as in other study populations. Median LOS is 15 days in the acute clinic and 39 days in the rehabilitation institution. The psychosocial outcome compares favorably to a matched control group.

Conclusions: A structured chain of acute stroke treatment overlapping with an early integrated rehabilitation is superior compared to national and international ischemic stroke trial data.

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Study Type : Observational
Enrollment : 200 participants
Observational Model: Defined Population
Time Perspective: Prospective
Official Title: Improved Stroke Outcome at 6 Months Attained by a Chain of Structured Acute Treatment With Integrated Rehabilitation and Supported Discharge
Study Start Date : January 2002
Study Completion Date : January 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Rehabilitation

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • An acute cerebrovascular event (ischemic stroke or intra-cerebral bleeding (ICB)) with the signs and symptoms of an acute stroke according to the World Health Organisation definition of acute stroke within the last 12 hours without the need or possibility of a neurosurgical intervention;
  • No thrombolytic therapy within the first 3 hours (in order to allow the correct comparison with the Swiss cohort of the IST trial)
  • The informed consent of the patient or, if not possible, of the next of kindred
  • Living at home before the event
  • Lack of participation in another trial

Exclusion Criteria:

  • Transient ischemic attack (TIA) resp. full recovery within 24 hours after the event

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00122798

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Kantonsspital Baden
Baden, Aargau, Switzerland, 5404
Sponsors and Collaborators
Kantonsspital Baden
RehaClinic Zurzach
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Principal Investigator: Juerg H Beer, M.D Dept of Medicine, Kantonsspital Baden, Switzerland
Additional Information:
Layout table for additonal information Identifier: NCT00122798    
Other Study ID Numbers: EK 50
First Posted: July 22, 2005    Key Record Dates
Last Update Posted: June 27, 2006
Last Verified: December 2004
Keywords provided by Kantonsspital Baden:
Stroke, stroke treatment, atrial fibrillation, medication, rehabilitation
Additional relevant MeSH terms:
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Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases