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Biological Imaging for Optimising Clinical Target Volume (CTV) and Gross Tumour Volume (GTV) Contouring in Prostate Cancer to Improve the Possibilities for Intensity Modulated RadioTherapy (IMRT) Dose Escalation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00122252
Recruitment Status : Terminated (Study abandoned.)
First Posted : July 22, 2005
Last Update Posted : December 9, 2011
Information provided by:
AHS Cancer Control Alberta

Brief Summary:
The clinical outcome after external beam irradiation for prostate cancer is disappointing in the advanced tumor stages. There are indications that an increase in radiation dose to the tumor will improve outcome significantly, especially to the biologically active tumour parts within the cancer area. Until recently no imaging equipment was available to define both the anatomic and biologically active tumor parts. Now, at the Center for Biological Imaging and Adaptive Radiotherapy, equipment is at hand that will be able to visualise the areas mentioned above. When combining the data of these imaging modalities it might be possible to create an optimised irradiation plan. This study is a planning study in which, on 15 patients, the different anatomical and biological imaging data per patient will be evaluated, matched and finally a theoretical improved irradiation treatment plan will be made. This research complies with the current opinion on radiation development. Progress in functional imaging is likely to provide the tools required for individualised risk-adapted radiotherapy.

Condition or disease
Prostate Cancer

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Study Type : Observational
Enrollment : 20 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Biological Imaging for Optimising CTV and GTV Contouring in Prostate Cancer to Improve the Possibilities for IMRT Dose Escalation
Study Start Date : May 2004
Actual Study Completion Date : February 2007

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Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
primary care clinic

Inclusion Criteria:

  • Histologically proven prostate adenocarcinoma

Exclusion Criteria:

  • Previous treatment for prostate cancer
  • Contraindications to magnetic resonance imaging (MRI)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00122252

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Canada, Alberta
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Sponsors and Collaborators
Alberta Health Services
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Principal Investigator: Matthew Parliament, MD Cross Cancer Institute
Layout table for additonal information Identifier: NCT00122252    
Other Study ID Numbers: GU-6-0045
First Posted: July 22, 2005    Key Record Dates
Last Update Posted: December 9, 2011
Last Verified: December 2011
Keywords provided by AHS Cancer Control Alberta:
prostate cancer
biological imaging
Additional relevant MeSH terms:
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Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Prostatic Diseases