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The Effect of Caffeine in Elderly Citizens

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00117520
Recruitment Status : Completed
First Posted : July 7, 2005
Last Update Posted : July 7, 2006
Information provided by:
Herning Hospital

Brief Summary:
The study investigated the effect of caffeine on physical performance in healthy citizens aged over 70 years. The main hypothesis was that 6 mg/kg caffeine would improve cycling endurance at 65% of expected maximal heart rate.

Condition or disease Intervention/treatment Phase
Healthy Elderly Citizens Drug: Caffeine Phase 4

Detailed Description:
Caffeine ingestion increases the endurance of young people exercising at 60%-85% of their maximal oxygen uptake, and it also seems to improve endurance as measured by repeated sub-maximal isometric contraction and decreases the rate of perceived exertion during exercise. Although caffeine increases endurance in young people, an increase in endurance may be of greater interest in the elderly as the population of older adults with a physically active lifestyle is growing rapidly or for increasing endurance fitness through an exercise or rehabilitation program. Therefore the main hypothesis was that caffeine would improve cycling endurance at 65% of expected maximal heart rate, and the secondary hypotheses were that caffeine would improve postural stability, reaction and movement times, isometric arm flexion endurance, and walking speed, and would reduce the rate of perceived exertion after 5 minutes of cycling in healthy elderly citizens.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: The Effect of Caffeine as Endurance Enhancing Drug in the Elderly
Study Start Date : July 2002
Study Completion Date : March 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Caffeine

Primary Outcome Measures :
  1. endurance measured on an ergometer bicycle

Secondary Outcome Measures :
  1. postural stability
  2. reactiontime
  3. isometric endurance (armflexion)
  4. walking speed
  5. fatigue

Information from the National Library of Medicine

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Ages Eligible for Study:   70 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy elderly individuals aged over 70 years

Exclusion Criteria:

  • Dementia or invalidating psychiatric disease
  • General debility, angina, or other diseases that would render participation in the test program impossible
  • Treatment with beta receptor blocking drugs, calcium-channel blocking drugs, digitalis, or nitroglycerine
  • Acute disease and injury
  • Diabetes
  • Conditions that would contraindicate caffeine ingestion or participation in the test program
  • Treatment with medication that interacts with caffeine
  • Ingestion of caffeine containing drinks and foods 48 hours before each session

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00117520

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Surgical Research Department
Herning, Ringkjoebing, Denmark, 7400
Sponsors and Collaborators
Herning Hospital
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Principal Investigator: Charlotte B Norager, M.D Surgical Research Department, Herning Hospital, DK-7400 Herning
Layout table for additonal information Identifier: NCT00117520    
Other Study ID Numbers: 2612-1987
First Posted: July 7, 2005    Key Record Dates
Last Update Posted: July 7, 2006
Last Verified: July 2002
Keywords provided by Herning Hospital:
caffeine, endurance, postural stability, elderly
Additional relevant MeSH terms:
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Central Nervous System Stimulants
Physiological Effects of Drugs
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Purinergic P1 Receptor Antagonists
Purinergic Antagonists
Purinergic Agents
Neurotransmitter Agents