Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood
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ClinicalTrials.gov Identifier: NCT00116311 |
Recruitment Status : Unknown
Verified March 2007 by Groningen Research Institute for Asthma and COPD.
Recruitment status was: Active, not recruiting
First Posted : June 29, 2005
Last Update Posted : March 21, 2007
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The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls. We hypothesize that asthmatics will have increased adenosine receptor expression versus control subjects.
We also want to study the effects of allergen inhalation on adenosine receptor expression in asthmatics. We believe that adenosine receptor expression will be upregulated after allergen inhalation.
Both hypotheses are being tested in sputum and peripheral blood.
Condition or disease | Intervention/treatment |
---|---|
Asthma Healthy | Behavioral: allergen inhalation Behavioral: withdrawal of medication Procedure: sputum induction |
Study Type : | Observational |
Enrollment : | 20 participants |
Observational Model: | Defined Population |
Time Perspective: | Other |
Official Title: | Effects of Allergen Inhalation on Adenosine Receptor Expression and Mast Cell Activation in Peripheral Blood and Sputum of Asthmatics and Healthy Subjects |
Study Start Date : | July 2005 |
Study Completion Date : | February 2007 |


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Ages Eligible for Study: | 18 Years to 50 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Asthmatic Subjects - Inclusion Criteria:
- Clinical diagnosis of asthma
- Steroid naive or subjects not using their inhaled steroids for the last 4 weeks, short-acting beta-agonist for rescue medication
- FEV1 > 70% of predicted
- Positive skin prick test for house dust mite, cat or grass pollen
- PC20 methacholine or histamine < 8 mg/ml
Asthmatic Subjects - Exclusion Criteria:
- Use of systemic steroids in the previous 6 weeks
- Asthma exacerbations in the previous 6 weeks
- Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who stopped less than 1 year ago
Healthy Subjects - Inclusion Criteria:
- No airway complaints
- FEV1 > 90% of predicted
- Negative skin prick test
- PC20 methacholine or histamine > 8 mg/ml
Healthy Subjects - Exclusion Criteria:
- Use of steroids in the previous 6 weeks
- Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who stopped less than 1 year ago

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00116311
Netherlands | |
University Medical Center Groningen, Department of Pulmonology | |
Groningen, Netherlands, 9713 GZ |
Principal Investigator: | Dirkje S Postma, prof. MD PhD | University Medical Center Groningen, Department of Pulmonology, hanzeplein 1, 9713 GZ Groningen, The Netherlands |
ClinicalTrials.gov Identifier: | NCT00116311 |
Other Study ID Numbers: |
METc2004-253 |
First Posted: | June 29, 2005 Key Record Dates |
Last Update Posted: | March 21, 2007 |
Last Verified: | March 2007 |
Adenosine receptors asthma sputum peripheral blood healthy |
Asthma Respiratory Aspiration Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases |
Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Respiration Disorders Pathologic Processes |