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Exercise Training and Walking Ability After Chronic Stroke

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00107068
Recruitment Status : Completed
First Posted : April 5, 2005
Last Update Posted : December 3, 2015
Information provided by:
University of Sydney

Brief Summary:
This study will investigate the efficacy of aerobic exercise and progressive resistance training (PRT), singularly and combined, on changes in walking endurance for mildly-to-moderately affected chronic stroke patients. Specifically, we will determine the relative importance of training induced changes in muscle strength versus aerobic fitness on increases in gait velocity and 6-min walking distance, and assess the concomitant functional and psychosocial impact of increased muscle strength, aerobic fitness and improved gait. This longitudinal study will be conducted as a double blinded factorial randomized controlled trial of exercise training for chronic stroke patients.

Condition or disease Intervention/treatment Phase
Stroke Procedure: [A] Aerobic isokinetic cycling exercise Procedure: [B] Progressive Resistance Training Procedure: [A] + [B] Not Applicable

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Study Type : Interventional  (Clinical Trial)
Enrollment : 48 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Does Aerobic or Resistance Exercise Training Improve Walking Ability in Chronic Stroke Patients?
Study Start Date : January 2001
Actual Primary Completion Date : March 2003
Actual Study Completion Date : May 2004

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Subjects will undertake a 6 min walking test for maximum distance

Secondary Outcome Measures :
  1. Cardiorespiratory Fitness
  2. Lower limb muscular strength and endurance
  3. Mobility variables
  4. Scales and questionnaires

Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age > 45 years
  • First stroke resulting in hemiplegia
  • At least 4-months post stroke
  • Residing at home or community-based (non-institutionalized) living environment
  • Self selected gait velocity between 0.42 m/s to 0.80 m/s
  • No longer receiving physiotherapy.
  • Adequate comprehension of instructions and perceptual abilities (assessed by stroke clinician during medical screening), no significant musculotendinous or bony restrictions of the affected limb, nor any serious chronic disease independently causing significant disability or profound atrophy of the affected limb will comprise further indications to participation

Exclusion Criteria:

  • Subjects will be excluded if they have significant cardiac disease, symptom limiting peripheral vascular disease, or any of the exclusion criteria contraindicating moderate exercise as outlined by the American College of Sports Medicine guidelines for cardiac disease rehabilitation or for frail and elderly adults. The initial symptom-limited/maximal aerobic assessment will serve as the screening test for contraindications to further exercise.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00107068

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Australia, New South Wales
Rehabilitation Research Centre, University of Sydney
Sydney, New South Wales, Australia, 2141
Sponsors and Collaborators
University of Sydney

Layout table for additonal information Identifier: NCT00107068     History of Changes
Other Study ID Numbers: NHMRC 153970
NHMRC 153970
First Posted: April 5, 2005    Key Record Dates
Last Update Posted: December 3, 2015
Last Verified: December 2015
Keywords provided by University of Sydney:
Walking ability
Additional relevant MeSH terms:
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Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases