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Intravenous CG7870 in Combination With Docetaxel in Patients With Metastatic Hormone-Refractory Prostate Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00103428
Recruitment Status : Terminated
First Posted : February 9, 2005
Last Update Posted : February 2, 2006
Information provided by:
Cell Genesys

Brief Summary:

V-0039 is a Phase 1/2 dose escalation trial of CG7870 in combination with Docetaxel in metastatic hormone-refractory patients who have not received chemotherapy.

All patients will receive docetaxel. In the dose escalation phase of the study, patients will receive treatment intravenously with CG7870 at one of up to four dose levels. In the Phase 2 portion of this study, additional patients will be added at the maximum tolerated dose that is determined in Phase 1.

Condition or disease Intervention/treatment Phase
Prostate Cancer Biological: CG7870 Phase 1 Phase 2

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Study Type : Interventional  (Clinical Trial)
Enrollment : 69 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase 1/2a Dose-Escalation Trial of Intravenous CG7870 in Combination With Docetaxel in Chemotherapy-Naïve Patients With Metastatic Hormone-Refractory Prostate Cancer
Study Start Date : August 2004

Resource links provided by the National Library of Medicine

Drug Information available for: Docetaxel

Primary Outcome Measures :
  1. Metastatic hormone refractory prostate cancer

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Histologically confirmed adenocarcinoma of the prostate
  • Metastatic prostate cancer deemed to be unresponsive or refractory to hormone therapy (after discontinuation of anti-androgen therapy)
  • Detectable metastases by bone scan, and/or CT scan, and/or MRI, and/or CXR
  • ECOG performance status 0-1

Exclusion Criteria:

  • Transitional cell, small cell, neuroendocrine, or squamous cell prostate cancer
  • History of deep vein thrombosis or pulmonary embolus
  • Patients taking anticoagulants (such as coumadin or Heparin). The use of aspirin while on study is acceptable.
  • History of a bleeding disorder or recent clinically significant bleeding
  • Seropositive for HIV
  • History of Hepatitis B, Hepatitis C, or chronic liver disease
  • Prior gene therapy or immunotherapy
  • Prior chemotherapy for prostate cancer
  • Radiation therapy within 4 weeks of the first treatment.
  • History of myocardial infarction within 6 months of the first treatment
  • History of cerebrovascular accident
  • History of previous malignancy, except for the following: adequately treated basal cell or squamous cell skin cancer, superficial bladder cancer, adequately treated Stage I or II cancer currently in complete remission, or any other cancer that has been in complete remission for at least 5 years
  • Evidence of active prostatitis
  • Known hypersensitivity to docetaxel or to other drugs formulated with polysorbate 80

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00103428

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United States, Texas
Mary Crowley Medical Research Center
Dallas, Texas, United States, 75246
Sponsors and Collaborators
Cell Genesys

Layout table for additonal information Identifier: NCT00103428    
Other Study ID Numbers: V-0039
First Posted: February 9, 2005    Key Record Dates
Last Update Posted: February 2, 2006
Last Verified: January 2006
Keywords provided by Cell Genesys:
prostate cancer
hormone refractory
chemotherapy naive
dose escalation
Additional relevant MeSH terms:
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Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Genital Diseases, Male
Prostatic Diseases
Antineoplastic Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs