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Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections

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ClinicalTrials.gov Identifier: NCT00084201
Recruitment Status : Completed
First Posted : June 9, 2004
Last Update Posted : November 30, 2006
Sponsor:
Information provided by:
National Center for Complementary and Integrative Health (NCCIH)

Study Description
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Brief Summary:
The purpose of study is to determine whether cranberry juice interacts with antibiotics used to treat urinary tract infections (UTIs).

Condition or disease Intervention/treatment Phase
Urinary Tract Infections Drug: Cranberry juice Drug: Amoxicillin Not Applicable

Detailed Description:

Although evidence of its effectiveness is limited, cranberry juice is widely used to prevent urinary tract infections (UTIs). However, recent studies have shown that cranberry juice may affect the way the body absorbs and metabolizes antibiotics used to treat UTIs. This study will determine whether concurrent cranberry juice administration lowers the urinary concentrations of two commonly used antibiotics, amoxicillin and cefaclor.

This study will involve children being treated for UTIs and adults without UTIs. All of the children will continue their prescribed amoxicillin/cefaclor treatment. After 7 to 10 days of antibiotic treatment, the children will be assigned to receive either cranberry juice for 2 days or no additional treatment. Urine samples will be collected from all child participants before and after the administration of cranberry juice to examine the excretion of the antibiotics.

Adult participants will receive two different doses of amoxicillin, with or without cranberry juice. Blood and urine samples will be collected to evaluate the effect of cranberry juice on the absorption and elimination of amoxicillin.

Study Design
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Study Type : Interventional  (Clinical Trial)
Enrollment : 18 participants
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Cranberry: Interactions With Anti-Infectious Agents
Study Start Date : July 2006
Study Completion Date : June 2007

Resource links provided by the National Library of Medicine

Drug Information available for: Amoxicillin

Arms and Interventions
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Outcome Measures
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Primary Outcome Measures :
  1. Drug Elmination

Secondary Outcome Measures :
  1. Drug absorption

Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   6 Years to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria for Children:

  • Urinary tract infection (UTI) treated with cefaclor or amoxicillin

Inclusion Criteria for Adults:

  • No UTI

Exclusion Criteria:

  • Allergies to antibiotics
  • Use of medications other than oral contraceptives
  • Pregnancy or breast-feeding
  • Smoker
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00084201


Locations
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United States, Washington
University of Washington
Seattle, Washington, United States, 98195
Sponsors and Collaborators
National Center for Complementary and Integrative Health (NCCIH)
Investigators
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Principal Investigator: Gail D Anderson, PhD University of Washington
More Information
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ClinicalTrials.gov Identifier: NCT00084201    
Other Study ID Numbers: R21AT002077-01 ( U.S. NIH Grant/Contract )
First Posted: June 9, 2004    Key Record Dates
Last Update Posted: November 30, 2006
Last Verified: November 2006
Keywords provided by National Center for Complementary and Integrative Health (NCCIH):
Vaccinium macrocarpon
Additional relevant MeSH terms:
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Infections
Urinary Tract Infections
Urologic Diseases
 Amoxicillin
Anti-Bacterial Agents
Anti-Infective Agents