Irinotecan and Capecitabine in Treating Women With Advanced Breast Cancer
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|ClinicalTrials.gov Identifier: NCT00083148|
Recruitment Status : Completed
First Posted : May 17, 2004
Last Update Posted : March 9, 2011
RATIONALE: Drugs used in chemotherapy, such as irinotecan and capecitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Irinotecan may help capecitabine kill more tumor cells by making tumor cells more sensitive to the drug.
PURPOSE: This phase I trial is studying the side effects and best dose of irinotecan and capecitabine in treating women with advanced breast cancer.
|Condition or disease||Intervention/treatment||Phase|
|Breast Cancer||Drug: capecitabine Drug: irinotecan hydrochloride||Phase 1|
- Determine the maximum tolerated dose of capecitabine and irinotecan in women with advanced breast cancer.
- Determine the degree of accumulation of cells in S-phase in tumor biopsies from patients treated with this regimen.
- Determine the dose-limiting toxicity and other major or unusual toxic effects of this regimen in these patients.
- Determine any antitumor activity of this regimen in these patients.
- Determine the pharmacokinetics of this regimen, including the active metabolite SN-38, in these patients.
- Correlate pharmacokinetic parameters of this regimen with the biological changes observed in these patients.
- Determine, preliminarily, the relationship of tumor response with modulation of S-phase in patients treated with this regimen.
OUTLINE: This is a dose-escalation study.
Patients receive irinotecan IV over 1.5 hours on days 1, 8, 22, and 29 and oral capecitabine twice daily on days 1-14 and 23-36. Treatment continues in the absence of disease progression or unacceptable toxicity.
Cohorts of 3-6 patients receive escalating doses of irinotecan and capecitabine until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.
PROJECTED ACCRUAL: A total of 8-37 patients will be accrued for this study within 18-24 months.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Single Group Assignment|
|Official Title:||Phase I Study of Irinotecan Followed by Capecitabine in Patients With Advanced Breast Carcinoma|
|Study Start Date :||November 2002|
|Actual Primary Completion Date :||March 2005|
|Actual Study Completion Date :||September 2006|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00083148
|United States, New York|
|Roswell Park Cancer Institute|
|Buffalo, New York, United States, 14263-0001|
|Principal Investigator:||Tracey O'Connor, MD||Roswell Park Cancer Institute|