Fetal Neurobehavioral Development in Methadone Maintained Pregnancies
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The purpose of this study is to examine differences in fetal neurobehavior at peak (2 hours after oral dose) vs. trough (2 hours before oral dose) maternal plasma methadone levels.
Condition or disease
Device: Toitu 320/325
This study will examine differences in fetal neurobehavior at peak (2 hours after oral dose) vs. trough (2 hours before oral dose) plasma methadone levels. Anecdotal clinical observations suggest that fetal activity is increased at trough methadone levels and decreased at peak methadone levels, yet the investigators do not understand how in utero methadone exposure affects fetal neurobehavioral state development.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 40 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Methadone exposed pregnancies
Actively enrolled pregnant patients in CAP SA treatment.
Maternal age 18-40 years
Single intrauterine fetus
Estimated gestational age of 32 weeks
DSMIV criteria for opioid dependence according to e-module of the SCID
Daily methadone maintenance at a stable dose for greater than a week
Concurrent DSMIV axis I diagnosis that would preclude informed consent procedures (i.e., schizophrenia, major depression) or confound study outcomes (e.g., Alcohol Dependence)
Presence of a serious medical or psychiatric illness requiring chronic medication or other intervention (i.e., HIV infection) that may confound data interpretation
Evidence of preterm labor
Evidence of prescription drug use (e.g., antidepressants, tranquilizers)
Presence of major congenital fetal malformation
Recent use (last month) of other illicit drugs (e.g., cocaine, marijuana) based on self report or positive on-Trak urine drug toxicology at time of actograph sessions